3-((6-(2,6-dimethylphenyl)-3-fluoropyridin-2-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5] cyclopenta[1,2-c]pyridine-6-carboxylic acid

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Chemical Name:3-((6-(2,6-dimethylphenyl)-3-fluoropyridin-2-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5] cyclopenta[1,2-c]pyridine-6-carboxylic acid
CAS No.:1544740-83-1
Molecular Formula:C₂₄H₂₁FN₂O₃
Molecular Weight:404.441
Hs Code.:

Synonyms:3-((6-(2,6-dimethylphenyl)-3-fluoropyridin-2-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5] cyclopenta[1,2-c]pyridine-6-carboxylic acid

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Chemical Property of 3-((6-(2,6-dimethylphenyl)-3-fluoropyridin-2-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5] cyclopenta[1,2-c]pyridine-6-carboxylic acid

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Technology Process of 3-((6-(2,6-dimethylphenyl)-3-fluoropyridin-2-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5] cyclopenta[1,2-c]pyridine-6-carboxylic acid

There total 16 articles about 3-((6-(2,6-dimethylphenyl)-3-fluoropyridin-2-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5] cyclopenta[1,2-c]pyridine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1544740-88-6
ethyl 3-((6-(2,6-dimethylphenyl)-3-fluoropyridin-2-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5] cyclopenta[1,2-c]pyridine-6-carboxylate

: 1544740-83-1
3-((6-(2,6-dimethylphenyl)-3-fluoropyridin-2-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5] cyclopenta[1,2-c]pyridine-6-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

Reference yield:

: 936011-17-5
5-bromo-2-methoxy-pyridine-4-carbaldehyde

: 1544740-83-1
3-((6-(2,6-dimethylphenyl)-3-fluoropyridin-2-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5] cyclopenta[1,2-c]pyridine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 12 h / 70 °C / 2585.81 Torr

2.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 20 °C

2.2: 1 h

3.1: palladium on activated charcoal; hydrogen / methanol / 2.5 h / 20 °C / 1551.49 Torr

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C

5.1: toluene-4-sulfonic acid / dimethyl sulfoxide; water / 2 h / 150 °C

6.1: methanol; sodium tetrahydroborate / 2 h / 0 - 20 °C

7.1: magnesium sulfate; Methyl p-tolyl sulfone / toluene / 2 h / 110 °C

8.1: dirhodium tetraacetate / dichloromethane / 8 h

9.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 2 h / Reflux

10.1: silver carbonate / toluene / 12 h / 100 °C

11.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

With methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dirhodium tetraacetate; sodium tetrahydroborate; chloro-trimethyl-silane; palladium on activated charcoal; water; hydrogen; sodium hexamethyldisilazane; sodium hydride; magnesium sulfate; toluene-4-sulfonic acid; triethylamine; Methyl p-tolyl sulfone; silver carbonate; sodium iodide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile; mineral oil;

Reference yield:

: 100379-00-8
2,6-dimethylbenzene boronic acid

: 1544740-83-1
3-((6-(2,6-dimethylphenyl)-3-fluoropyridin-2-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5] cyclopenta[1,2-c]pyridine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran; water / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

2: selenium(IV) oxide / 1,4-dioxane / 12 h / 100 °C

3: methanol; sodium tetrahydroborate / 1 h / 0 °C

4: phosphorus tribromide / tetrahydrofuran / 3 h / 0 - 20 °C

5: silver carbonate / toluene / 12 h / 100 °C

6: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; methanol; selenium(IV) oxide; sodium tetrahydroborate; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; phosphorus tribromide; silver carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene;