2-[8-Benzyloxy-2-ethyl-3-(4-pentyl-cyclohexylmethyl)-indolizin-1-yl]-2-oxo-acetamide

Base Information

Chemical Name:2-[8-Benzyloxy-2-ethyl-3-(4-pentyl-cyclohexylmethyl)-indolizin-1-yl]-2-oxo-acetamide
CAS No.:177557-39-0
Molecular Formula:C₃₁H₄₀N₂O₃
Molecular Weight:488.67
Hs Code.:

Synonyms:2-[8-Benzyloxy-2-ethyl-3-(4-pentyl-cyclohexylmethyl)-indolizin-1-yl]-2-oxo-acetamide

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Chemical Property of 2-[8-Benzyloxy-2-ethyl-3-(4-pentyl-cyclohexylmethyl)-indolizin-1-yl]-2-oxo-acetamide

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Technology Process of 2-[8-Benzyloxy-2-ethyl-3-(4-pentyl-cyclohexylmethyl)-indolizin-1-yl]-2-oxo-acetamide

There total 8 articles about 2-[8-Benzyloxy-2-ethyl-3-(4-pentyl-cyclohexylmethyl)-indolizin-1-yl]-2-oxo-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [8-Benzyloxy-2-ethyl-3-(4-pentyl-cyclohexylmethyl)-indolizin-1-yl]-oxo-acetyl chloride

: 177557-39-0
2-[8-Benzyloxy-2-ethyl-3-(4-pentyl-cyclohexylmethyl)-indolizin-1-yl]-2-oxo-acetamide

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; Yield given; Ambient temperature;
DOI:10.1021/jm960395q

Reference yield:

: 1121-25-1,55780-69-3
2-methyl-3-pyridinol

: 177557-39-0
2-[8-Benzyloxy-2-ethyl-3-(4-pentyl-cyclohexylmethyl)-indolizin-1-yl]-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / KOH, tetrabutylammonium bromide / tetrahydrofuran / 1.5 h / Ambient temperature

2: 90.1 percent / ethyl acetate / 0.5 h / 70 °C

3: 79 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / 0.75 h / Heating

4: 41 percent / benzene / 4 h / Heating

5: NaBH₄, AlCl₃ / tetrahydrofuran / 0.75 h / Heating

6: tetrahydrofuran / 0 °C

7: aq. NH₄OH / tetrahydrofuran / Ambient temperature

With potassium hydroxide; ammonium hydroxide; sodium tetrahydroborate; aluminium trichloride; tetrabutylammomium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/jm960395q

Reference yield:

: 100-39-0
benzyl bromide

: 177557-39-0
2-[8-Benzyloxy-2-ethyl-3-(4-pentyl-cyclohexylmethyl)-indolizin-1-yl]-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / KOH, tetrabutylammonium bromide / tetrahydrofuran / 1.5 h / Ambient temperature

2: 90.1 percent / ethyl acetate / 0.5 h / 70 °C

3: 79 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / 0.75 h / Heating

4: 41 percent / benzene / 4 h / Heating

5: NaBH₄, AlCl₃ / tetrahydrofuran / 0.75 h / Heating

6: tetrahydrofuran / 0 °C

7: aq. NH₄OH / tetrahydrofuran / Ambient temperature

With potassium hydroxide; ammonium hydroxide; sodium tetrahydroborate; aluminium trichloride; tetrabutylammomium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/jm960395q