but-2-enoic acid 1-(2-formylbenzyl)-2-methylpropyl ester

Base Information

• Chemical Name: but-2-enoic acid 1-(2-formylbenzyl)-2-methylpropyl ester
• CAS No.: 942062-95-5
• Molecular Formula: C₁₆H₂₀O₃
• Molecular Weight: 260.333
• Mol file: 942062-95-5.mol

Synonyms:but-2-enoic acid 1-(2-formylbenzyl)-2-methylpropyl ester

Chemical Property of but-2-enoic acid 1-(2-formylbenzyl)-2-methylpropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of but-2-enoic acid 1-(2-formylbenzyl)-2-methylpropyl ester

There total 6 articles about but-2-enoic acid 1-(2-formylbenzyl)-2-methylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

but-2-enoic acid 1-(2-hydroxymethylbenzyl)-2-methylpropyl ester (942062-94-4) → but-2-enoic acid 1-(2-formylbenzyl)-2-methylpropyl ester (942062-95-5)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 14h;

DOI:10.1021/ol0704901

Reference yield:

2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethanol (888324-77-4) → but-2-enoic acid 1-(2-formylbenzyl)-2-methylpropyl ester (942062-95-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 92 percent / Dess-Martin periodinane / CH₂Cl₂ / 14 h / 20 °C

2.1: diethyl ether; tetrahydrofuran / 1 h / 0 °C

2.2: 75 percent / NH₄Cl / diethyl ether; tetrahydrofuran; H₂O

3.1: 64 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / 0 °C

4.1: 89 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.75 h / 0 °C

5.1: 97 percent / Dess-Martin periodinane / CH₂Cl₂ / 14 h / 20 °C

With dmap; tetrabutyl ammonium fluoride; Dess-Martin periodane; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; 1.1: Dess-Martin oxidation / 5.1: Dess-Martin oxidation;

DOI:10.1021/ol0704901

Reference yield:

but-2-enoic acid 1-[2-((tert-butyldimethylsilanyloxy)methyl)benzyl]-2-methylpropyl ester (942062-93-3) → but-2-enoic acid 1-(2-formylbenzyl)-2-methylpropyl ester (942062-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.75 h / 0 °C

2: 97 percent / Dess-Martin periodinane / CH₂Cl₂ / 14 h / 20 °C

With tetrabutyl ammonium fluoride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; 2: Dess-Martin oxidation;

DOI:10.1021/ol0704901

upstream raw materials:

but-2-enoic acid 1-(2-hydroxymethylbenzyl)-2-methylpropyl ester

2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethanol

2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]acetaldehyde

1-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]-3-methylbutan-2-ol