but-2-enoic acid 1-[2-((tert-butyldimethylsilanyloxy)methyl)benzyl]-2-methylpropyl ester

Base Information

Chemical Name:but-2-enoic acid 1-[2-((tert-butyldimethylsilanyloxy)methyl)benzyl]-2-methylpropyl ester
CAS No.:942062-93-3
Molecular Formula:C₂₂H₃₆O₃Si
Molecular Weight:376.612
Hs Code.:

Synonyms:but-2-enoic acid 1-[2-((tert-butyldimethylsilanyloxy)methyl)benzyl]-2-methylpropyl ester

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Chemical Property of but-2-enoic acid 1-[2-((tert-butyldimethylsilanyloxy)methyl)benzyl]-2-methylpropyl ester

Chemical Property:

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Technology Process of but-2-enoic acid 1-[2-((tert-butyldimethylsilanyloxy)methyl)benzyl]-2-methylpropyl ester

There total 5 articles about but-2-enoic acid 1-[2-((tert-butyldimethylsilanyloxy)methyl)benzyl]-2-methylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 942062-92-2
1-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]-3-methylbutan-2-ol

: 623-68-7
trans-crotonic anhydride

: 942062-93-3
but-2-enoic acid 1-[2-((tert-butyldimethylsilanyloxy)methyl)benzyl]-2-methylpropyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1021/ol0704901

Reference yield:

: 888324-77-4
2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethanol

: 942062-93-3
but-2-enoic acid 1-[2-((tert-butyldimethylsilanyloxy)methyl)benzyl]-2-methylpropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 92 percent / Dess-Martin periodinane / CH₂Cl₂ / 14 h / 20 °C

2.1: diethyl ether; tetrahydrofuran / 1 h / 0 °C

2.2: 75 percent / NH₄Cl / diethyl ether; tetrahydrofuran; H₂O

3.1: 64 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / 0 °C

With dmap; Dess-Martin periodane; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; 1.1: Dess-Martin oxidation;
DOI:10.1021/ol0704901

Reference yield:

: 942062-87-5
2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]acetaldehyde

: 942062-93-3
but-2-enoic acid 1-[2-((tert-butyldimethylsilanyloxy)methyl)benzyl]-2-methylpropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethyl ether; tetrahydrofuran / 1 h / 0 °C

1.2: 75 percent / NH₄Cl / diethyl ether; tetrahydrofuran; H₂O

2.1: 64 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 4 h / 0 °C

With dmap; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ol0704901