ethyl 5-amino-3,4-dihydro-3-(4-methoxyphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate

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Chemical Name:ethyl 5-amino-3,4-dihydro-3-(4-methoxyphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate
CAS No.:123542-48-3
Molecular Formula:C₁₆H₁₅N₃O₄S
Molecular Weight:345.379
Hs Code.:

Synonyms:ethyl 5-amino-3,4-dihydro-3-(4-methoxyphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate

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Chemical Property of ethyl 5-amino-3,4-dihydro-3-(4-methoxyphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate

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Technology Process of ethyl 5-amino-3,4-dihydro-3-(4-methoxyphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate

There total 4 articles about ethyl 5-amino-3,4-dihydro-3-(4-methoxyphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 123565-82-2
ethyl 5-cyano-1-(4-methoxyphenyl)-4-methyl-6-oxo-1,6-dihydropyridazine-3-carboxylate

: 123542-48-3
ethyl 5-amino-3,4-dihydro-3-(4-methoxyphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate

Guidance literature:: With 4-methyl-morpholine; sulfur; In ethanol; at 90 ℃; for 6h;
DOI:10.1021/jm800557d

Reference yield:

: 18794-95-1,77083-79-5,77098-98-7
3-oxo-2-(2-(4-methoxyphenyl)hydrazono)butanoic acid ethyl ester

: 123542-48-3
ethyl 5-amino-3,4-dihydro-3-(4-methoxyphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 83.3 percent / ammonium acetate / 0.5 h / 140 °C

2: 71 percent / acetic acid, hydrochloric acid / 2 h / Heating

3: 79 percent / sulphur, piperidine / 4 h / Heating

With piperidine; ammonium acetate; hydrogenchloride; sulfur; acetic acid;

Reference yield:

: 104-94-9
4-methoxy-aniline

: 123542-48-3
ethyl 5-amino-3,4-dihydro-3-(4-methoxyphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / ethanol; water / 0.33 h / 0 °C

1.2: 2 h / 0 °C

2.1: ammonium acetate; acetic acid / 0.75 h / 120 °C / Microwave irradiation

3.1: sulfur; morpholine / ethanol / 0.42 h / 130 °C / Microwave irradiation

With morpholine; hydrogenchloride; ammonium acetate; sulfur; acetic acid; sodium nitrite; In ethanol; water;