Technology Process of (2S,2S')-(3,4-dichlorophenyl)(tetrahydropyran-2-yl)acetic acid menthyl ester
There total 5 articles about (2S,2S')-(3,4-dichlorophenyl)(tetrahydropyran-2-yl)acetic acid menthyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 75 percent / HCl gas / diethyl ether / 2 h
2.1: LDA / hexane; tetrahydrofuran / 2 h / 0 °C
2.2: 3.4 g / hexane; tetrahydrofuran / 22 °C
3.1: 65 percent / trimethylsilyl iodide / CHCl3 / 80 °C
4.1: DMF; (COCl)2 / CH2Cl2 / 3 h / 22 °C
5.1: 425 mg / pyridine / tetrahydrofuran
With
pyridine; hydrogenchloride; oxalyl dichloride; trimethylsilyl iodide; N,N-dimethyl-formamide; lithium diisopropyl amide;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; chloroform;
DOI:10.1021/jm0205292
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: LDA / hexane; tetrahydrofuran / 2 h / 0 °C
1.2: 3.4 g / hexane; tetrahydrofuran / 22 °C
2.1: 65 percent / trimethylsilyl iodide / CHCl3 / 80 °C
3.1: DMF; (COCl)2 / CH2Cl2 / 3 h / 22 °C
4.1: 425 mg / pyridine / tetrahydrofuran
With
pyridine; oxalyl dichloride; trimethylsilyl iodide; N,N-dimethyl-formamide; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane; chloroform;
DOI:10.1021/jm0205292
- Guidance literature:
-
Multi-step reaction with 2 steps
1: DMF; (COCl)2 / CH2Cl2 / 3 h / 22 °C
2: 425 mg / pyridine / tetrahydrofuran
With
pyridine; oxalyl dichloride; N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0205292
