Technology Process of 5-(1H-pyrazol-5-yl)-3-[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazole
There total 8 articles about 5-(1H-pyrazol-5-yl)-3-[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1H-pyrazole-3-carboxylic acid;
With
thionyl chloride;
at 80 ℃;
for 3h;
N'-hydroxy-1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazole-4-carboximidamide;
With
triethylamine;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 3.5 h / 20 °C
2.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tetrahydrofuran / 12 h / 60 °C
3.1: potassium cyanide; ammonia / methanol / 16 h / 80 °C / sealed tube
4.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0.5 h / 0 °C
5.1: hydroxylamine hydrochloride; triethylamine / ethanol / 1 h / 80 °C
6.1: thionyl chloride / 3 h / 80 °C
6.2: 1 h / 80 °C
With
potassium cyanide; thionyl chloride; diphenyl phosphoryl azide; hydroxylamine hydrochloride; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic anhydride;
copper(ll) sulfate pentahydrate; sodium L-ascorbate;
In
tetrahydrofuran; methanol; ethanol; water; toluene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 10.25 h / 0 - 60 °C
1.2: 0 °C
2.1: tert.-butylnitrite; copper dichloride / acetonitrile / 1.58 h / 20 °C
3.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 3.5 h / 20 °C
4.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tetrahydrofuran / 12 h / 60 °C
5.1: potassium cyanide; ammonia / methanol / 16 h / 80 °C / sealed tube
6.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0.5 h / 0 °C
7.1: hydroxylamine hydrochloride; triethylamine / ethanol / 1 h / 80 °C
8.1: thionyl chloride / 3 h / 80 °C
8.2: 1 h / 80 °C
With
potassium cyanide; lithium aluminium tetrahydride; thionyl chloride; tert.-butylnitrite; diphenyl phosphoryl azide; hydroxylamine hydrochloride; ammonia; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic anhydride; copper dichloride;
copper(ll) sulfate pentahydrate; sodium L-ascorbate;
In
tetrahydrofuran; methanol; ethanol; water; toluene; acetonitrile;
