(3-{3-[1-(3,4,5-Trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)acetic acid

Base Information

Chemical Name:(3-{3-[1-(3,4,5-Trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)acetic acid
CAS No.:1213234-75-3
Molecular Formula:C₁₆H₁₀Cl₃N₇O₃
Molecular Weight:454.659
Hs Code.:

Synonyms:(3-{3-[1-(3,4,5-Trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)acetic acid

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Chemical Property of (3-{3-[1-(3,4,5-Trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)acetic acid

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Technology Process of (3-{3-[1-(3,4,5-Trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)acetic acid

There total 10 articles about (3-{3-[1-(3,4,5-Trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1213235-13-2
ethyl (3-{3-[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)acetate

: 1213234-75-3
(3-{3-[1-(3,4,5-Trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)acetic acid

Guidance literature:: ethyl (3-{3-[1-(3,4,5-trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)acetate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 0.166667h;

With hydrogenchloride; In water; ethyl acetate; for 0.25h;

Reference yield:

: 7520-67-4
3,4,5-trichloro-benzyl alcohol

: 1213234-75-3
(3-{3-[1-(3,4,5-Trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 3.5 h / 20 °C

2.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tetrahydrofuran / 12 h / 60 °C

3.1: potassium cyanide; ammonia / methanol / 16 h / 80 °C / sealed tube

4.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0.5 h / 0 °C

5.1: hydroxylamine hydrochloride; triethylamine / ethanol / 1 h / 80 °C

6.1: thionyl chloride / 3 h / 80 °C

6.2: 1 h / 80 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.17 h / 20 °C

8.2: 0.25 h

With potassium cyanide; thionyl chloride; diphenyl phosphoryl azide; hydroxylamine hydrochloride; ammonia; water; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic anhydride; sodium hydroxide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 56961-25-2
4-amino-3,5-dichlorobenzoic acid

: 1213234-75-3
(3-{3-[1-(3,4,5-Trichlorobenzyl)-1H-1,2,3-triazol-4-yl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 10.25 h / 0 - 60 °C

1.2: 0 °C

2.1: tert.-butylnitrite; copper dichloride / acetonitrile / 1.58 h / 20 °C

3.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 3.5 h / 20 °C

4.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tetrahydrofuran / 12 h / 60 °C

5.1: potassium cyanide; ammonia / methanol / 16 h / 80 °C / sealed tube

6.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 0.5 h / 0 °C

7.1: hydroxylamine hydrochloride; triethylamine / ethanol / 1 h / 80 °C

8.1: thionyl chloride / 3 h / 80 °C

8.2: 1 h / 80 °C

9.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

10.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0.17 h / 20 °C

10.2: 0.25 h

With potassium cyanide; lithium aluminium tetrahydride; thionyl chloride; tert.-butylnitrite; diphenyl phosphoryl azide; hydroxylamine hydrochloride; ammonia; water; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic anhydride; sodium hydroxide; copper dichloride; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;