3-{ 4-[(2-butyl-5-nitro-1-benzofuran-3-yl) carbonyl]phenoxy}propan-1-ol

Base Information

Chemical Name:3-{ 4-[(2-butyl-5-nitro-1-benzofuran-3-yl) carbonyl]phenoxy}propan-1-ol
CAS No.:1310430-11-5
Molecular Formula:C₂₂H₂₃NO₆
Molecular Weight:397.428
Hs Code.:

Synonyms:3-{ 4-[(2-butyl-5-nitro-1-benzofuran-3-yl) carbonyl]phenoxy}propan-1-ol

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Chemical Property of 3-{ 4-[(2-butyl-5-nitro-1-benzofuran-3-yl) carbonyl]phenoxy}propan-1-ol

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Technology Process of 3-{ 4-[(2-butyl-5-nitro-1-benzofuran-3-yl) carbonyl]phenoxy}propan-1-ol

There total 1 articles about 3-{ 4-[(2-butyl-5-nitro-1-benzofuran-3-yl) carbonyl]phenoxy}propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 141645-16-1
2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

: 627-30-5
1-chloro-3-hydroxypropane

: 1310430-11-5
3-{ 4-[(2-butyl-5-nitro-1-benzofuran-3-yl) carbonyl]phenoxy}propan-1-ol

Guidance literature:: 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran; With tetrabutylammomium bromide; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 50 ℃; for 0.5h;

1-chloro-3-hydroxypropane; In N,N-dimethyl-formamide; at 80 - 85 ℃;

Reference yield: 91.0%

: 1310430-11-5
3-{ 4-[(2-butyl-5-nitro-1-benzofuran-3-yl) carbonyl]phenoxy}propan-1-ol

: 1310430-13-7
3-{4-[(5-amino-2-butyl-1-benzofuran-3-yl)carbonyl]phenoxy}propan-1-ol

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; water; at 40 ℃; under 3000.3 Torr; Autoclave;

Reference yield:

: 1310430-11-5
3-{ 4-[(2-butyl-5-nitro-1-benzofuran-3-yl) carbonyl]phenoxy}propan-1-ol

: 141625-93-6
dronedarone hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / water; methanol / 40 °C / 3000.3 Torr / Autoclave

2.1: pyridine / dichloromethane / 24 h / 10 - 20 °C

3.1: acetonitrile / Reflux

3.2: 2 h / 40 °C

With pyridine; hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane; water; acetonitrile;