141625-93-6 Usage
Chemical Properties
Pale Yellow Solid
Uses
Different sources of media describe the Uses of 141625-93-6 differently. You can refer to the following data:
1. Dronedarone Hydrochloride is a therapy for the treatment of patients with paroxysmal and persistent atrial fibrillation or atrial flutter.
2. Cardiovascular Drugs
3. Dronedarone Hydrochloride can be used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.
Biological Activity
dronedarone hcl is an amiodarone analogue which has been shown an effective and promising treatment for atrial fibrillation (af) [1].
Biochem/physiol Actions
Dronedarone is a Class III antiarrhythmic and a multi-channel blocker for atrial fibrillation. It blocks potassium, sodium, and calcium channels and also exhibits antiadrenergic properties.
Clinical Use
Dronedarone hydrochloride (also known as SR33589 and marketed
as Multaq) is a drug developed by Sanofi-Aventis for cardiac
arrhythmias (irregular heartbeat) that was approved by the FDA in
July 2009. Dronedarone is used for the treatment of atrial fibrillation
and atrial flutter in patients whose hearts have either returned
to normal rhythm or who undergo drug therapy or
electroshock treatment to maintain normal cardio rhythm. Dronedarone
is less lipophilic than amiodarone, exhibits a much smaller
volume of distribution and a half-life of 24 h, this stands in contrast
to competitor amiodarone’s half-life of several weeks. As
a result of these pharmacokinetic characteristics, dronedarone
dosing may be less complicated than amiodarone.
Synthesis
The synthesis
of dronedarone relies on the preparation of the benzofuran core
34, of which three main routes have been reported, but two possess
obvious overlap and are considered more process-amenable.
Starting from methyl 2-(2-formylphenoxy)hexanoate (32), this aldehyde can either be nitrated, then saponified or saponified
and then nitrated to procure nitroacid 33 (the Scheme). The benzofuran
ring is then secured through the use of acetic anhydride and
base in the presence of DMF at elevated temperature. The key benzofuran
34 can be produced by either route in 62% yield on gramscale
by this method. Friedel–Crafts acylation involving anisoyl
chloride and tin tetrachloride constructed the diaryl ketone 35.
Cleavage of the methyl ether through the use of aluminum trichloride
in refluxing DCE provided phenol 36. Alkylation of phenol 36
with aminoalkyl chloride 37 gave ether 38. Subsequent reduction
of the nitro group via catalytic hydrogenation and sulfonylation
of the resulting amine provided dronedarone (VII) which was isolated
as its HCl salt.
in vitro
dronedarone has been demonstrated to inhibit muscarinic acetylcholine receptor-operated k+ current ik(ach) induced by carbachol or gtp-gamma-s with ic50 values of 10nm and <100nm, respectively, in cells isolated from guinea pig atria. notably, dronedarone was 100-fold potent and selective over amiodarone in inhibiting ik(ach) [1].
in vivo
dronedarone has shown to block arterial thrombus formation, decrease platelet aggregation and reduce plasminogen activator inhibitor-1 (pai1) expression in c57bl/6 mice [2].
references
[1] guillemare e1, marion a, nisato d, gautier p. inhibitory effects of dronedarone on muscarinic k+ current in guinea pig atrial cells. j cardiovasc pharmacol. 2000 dec;36(6):802-5.[2] breitenstein a1, sluka sh, akhmedov a, stivala s, steffel j, camici gg, riem hh, beer hj, studt jd, duru f, luscher tf, tanner fc. dronedarone reduces arterial thrombus formation. basic res cardiol. 2012 nov;107(6):302.
Check Digit Verification of cas no
The CAS Registry Mumber 141625-93-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,6,2 and 5 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 141625-93:
(8*1)+(7*4)+(6*1)+(5*6)+(4*2)+(3*5)+(2*9)+(1*3)=116
116 % 10 = 6
So 141625-93-6 is a valid CAS Registry Number.
InChI:InChI=1/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3;/h13-18,23,32H,5-12,19-22H2,1-4H3;1H
141625-93-6Relevant articles and documents
An improved scalable route to pure dronedarone hydrochloride
Hivarekar, Raghvendra R.,Deshmukh, Sanjay S.,Tripathy., Narendra K.
, p. 677 - 681 (2012)
An efficient scalable synthesis for dronedarone hydrochloride (2) via Friedel-Craft acylation of 2-(-2-butyl-1-benzofuran-5-yl)-1H-isoindole-1,3(2H) dione (12) with 4-(3-chloropropoxy) benzoic acid (13) in good yield and high purity has been developed by using Eaton's reagent instead of hazardous and toxic metal halide catalyst like AlCl3 or SnCl4.
Preparation method for dronedarone hydrochloride
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Paragraph 0070-0072; 0077-0085, (2019/03/15)
The invention relates to a preparation method for dronedarone hydrochloride. The preparation method includes utilizing 1,4-cyclohexanedione as a raw material to generate dihalogenated-1,4-cyclohexanedione through halogenation reaction with chlorine or bro
Method for synthesizing [...] reach silom
-
, (2017/01/17)
The invention discloses a dronedarone synthesis method. According to the method, 4-[3-(dibutylamino)propoxy]methyl benzoate, 4-[3-(dibutylamino)propoxy]benzoic acid hydrochloride, 4-[3-(dibutylamino)propoxy]benzoyl chloride, 2-bromohexanoyl chloride, p-methoxyacetanilide, 3-(2-bromohexanoyl chloride)-4-hydroxyacetanilide, N-2-butyl-5-benzofuranamine hydrochloride, N-[(2-butyl-2,3-2H-5-benzofuran)methanesulfonamide], N-2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuran]-methanesulfonamide and dronedarone are obtained through step-reactions. The dronedarone synthesis method is simple in process, convenient to operate and high in rate of production.
PROCESS FOR PREPARING DRONEDARONE AND SALTS THEREOF
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Page/Page column 13; 14; 15, (2015/03/16)
The present disclosure relates to processes for preparing dronedarone or pharmaceutically acceptable salts thereof.
