ethyl 3-[benzyl(cyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate

Base Information

• Chemical Name: ethyl 3-[benzyl(cyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate
• CAS No.: 1610517-28-6
• Molecular Formula: C₁₈H₂₁Cl₂NO₃
• Molecular Weight: 370.276
• Mol file: 1610517-28-6.mol

Synonyms:ethyl 3-[benzyl(cyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate

Chemical Property of ethyl 3-[benzyl(cyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-[benzyl(cyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate

There total 4 articles about ethyl 3-[benzyl(cyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,2-dichloro-2-ethoxycarbonylacetyl chloride (1610517-27-5) + N-benzyl-N-(3-cyclohexenyl)amine (187807-23-4) → ethyl 3-[benzyl(cyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate (1610517-28-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201301590

Reference yield:

4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohex-1-ene (422507-09-3) → ethyl 3-[benzyl(cyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate (1610517-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; water / tetrahydrofuran / 2 h / Reflux

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; water; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/ejoc.201301590

Reference yield:

C18H27NO3 → ethyl 3-[benzyl(cyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate (1610517-28-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

1.2: 24 h / 90 °C / Inert atmosphere

2.1: hydrogenchloride; water / tetrahydrofuran / 2 h / Reflux

3.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; water; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/ejoc.201301590

upstream raw materials:

4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohex-1-ene

2,2-dichloro-2-ethoxycarbonylacetyl chloride

N-benzyl-N-(3-cyclohexenyl)amine

ethyl chlorocarbonylacetate