187807-23-4

Upstream product

• 100-46-9 benzylamine 
• 422507-09-3 4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohex-1-ene 
• 422507-52-6 4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohexan-1-one p-toluensulfonylhydrazone 
• 188562-91-6 tert-butyl N-benzyl(4-oxocyclohexyl)carbamate 
• 188562-93-8 4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohex-1-en-yl trifluoromethanesulfonate 
• 422507-07-1 trans-4-[N-benzyl-N-(tert-butoxycarbonyl)amino]cyclohexan-1-ol 
• 142009-99-2 4-(benzylamino)cyclohexane-1-one 
• 162338-03-6 N-benzyl-trans-4-aminocyclohexanol 

Downstream Products

• 422507-12-8 4-[N-benzyl-N-(methoxycarbonylmethyl)amino]-1-cyclohexene 
• 1610517-28-6 ethyl 3-[benzyl(cyclohex-3-en-1-yl)amino]-2,2-dichloro-3-oxopropanoate 
• 187807-24-5 4-{benzyl-[2-(methylselanyl)-2-oxoethyl]amino}cyclohex-1-ene 

Relevant academic research and scientific papers

Chlorine atom transfer radical 6-exo cyclizations of carbamoyldichloroacetate-tethered alkenes, enol acetates and α,β-unsaturated nitriles leading to morphans

The CuI-mediated atom transfer radical cyclization of amino-tethered dichloromalonamides and electron-rich, electron-poor, and nonactivated double bonds is a useful methodology for the synthesis of 2-azabicyclo[3.3.1]nonanes. A study of the rea

A simple and efficient synthesis of N-substituted cyclohex-3-enamines

A straightforward preparation of N-substituted cyclohex-3-enamines starting from the commercially available trans-4-aminocyclohexanol hydrochloride is described. Cyclohex-3-enamino-functionalized compounds have proven to be interesting intermediates in me

Decarbonylative radical cyclization of α-amino selenoesters upon electrophilic alkenes. A general method for the 6-azabicyclo[3.2.1]octane synthesis

α-Amino selenoester-tethered electronically poor alkenes on treatment with tributyltin hydride or TTMSS undergo intramolecular radical cyclization to provide 6-azabicyclo[3.2.1]octanes through 1-aminomethyl radical intermediates.

A New Method to Generate α-Aminoalkyl Radicals: Treatment of Methyl α-Amino Selenoesters with Hydride Reagents. Synthesis of 6-Azabicyclo[3.2.1]octanes by Radical Cyclization

A new method to generate α-aminoalkyl radicals and its application to the synthesis of 6-azabicyclo[3.2.1]octanes is described. α-Amino selenoesters on heating with Bu3SnH or (Me3Si)3SiH undergo decarbonylation of the initially formed acyl radical to give the corresponding α-amino radical which could be trapped intramolecularly with a double bond bearing an electron-withdrawing group.

A simple method of preparation of 7-alkyl-7-azabicyclo[2.2.1] heptanes

Action of triphenylphosphine - carbon tetrachloride on the trans-4-alkylaminocyclohexanols leads to 7-alkyl-7-azabicyclo[2.2.1]heptanes in the good yields. The starting aminoalcohols are easily available from the monoethylene ketal of 1,4-cyclohexanedione and primary amines in a four step process without isolation of intermediates.