trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester
• CAS No.: 1394011-79-0
• Molecular Formula: C₂₄H₂₇ClF₃N₃O₄
• Molecular Weight: 513.944
• Mol file: 1394011-79-0.mol

Synonyms:trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester

Chemical Property of trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester

There total 6 articles about trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

trans-1-(4-chloro-3-trifluoromethylphenyl)-3-(4-hydroxycyclohexyl)urea (1394011-78-9) + tert-butyl 4-chloropyridine-2-carboxylate (220000-86-2) → trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester (1394011-79-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 87.0%

trans-1-(4-hydroxycyclohexyl)-3-(4-trifluoromethoxyphenyl)urea (1394011-82-5) + tert-butyl 4-chloropyridine-2-carboxylate (220000-86-2) → trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester (1394011-79-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.05.011

Reference yield:

4-chloro-pyridine-2-carbonyl chloride (53750-66-6) → trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester (1394011-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1,2-dichloro-ethane / 0 - 50 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With pyridine; potassium tert-butylate; In tetrahydrofuran; 1,2-dichloro-ethane;

upstream raw materials:

4-chloro-3-(trifluoromethyl)phenyl isocyanate

trans-1-(4-chloro-3-trifluoromethylphenyl)-3-(4-hydroxycyclohexyl)urea

tert-butyl 4-chloropyridine-2-carboxylate

4-chloro-pyridine-2-carbonyl chloride

Downstream raw materials:

C₂HF₃O₂*C₂₀H₁₉ClF₃N₃O₄

t-CUPM

trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid dimethylamide