trans-1-(4-chloro-3-trifluoromethylphenyl)-3-(4-hydroxycyclohexyl)urea

Base Information

• Chemical Name: trans-1-(4-chloro-3-trifluoromethylphenyl)-3-(4-hydroxycyclohexyl)urea
• CAS No.: 1394011-78-9
• Molecular Formula: C₁₄H₁₆ClF₃N₂O₂
• Molecular Weight: 336.741
• Mol file: 1394011-78-9.mol

Synonyms:trans-1-(4-chloro-3-trifluoromethylphenyl)-3-(4-hydroxycyclohexyl)urea

Chemical Property of trans-1-(4-chloro-3-trifluoromethylphenyl)-3-(4-hydroxycyclohexyl)urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of trans-1-(4-chloro-3-trifluoromethylphenyl)-3-(4-hydroxycyclohexyl)urea

There total 1 articles about trans-1-(4-chloro-3-trifluoromethylphenyl)-3-(4-hydroxycyclohexyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

trans-4-aminocyclohexanol hydrochloride (50910-54-8) + 4-chloro-3-(trifluoromethyl)phenyl isocyanate (327-78-6) → trans-1-(4-chloro-3-trifluoromethylphenyl)-3-(4-hydroxycyclohexyl)urea (1394011-78-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 88.0%

trans-1-(4-chloro-3-trifluoromethylphenyl)-3-(4-hydroxycyclohexyl)urea (1394011-78-9) + tert-butyl 4-chloropyridine-2-carboxylate (220000-86-2) → trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester (1394011-79-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 86.0%

4-fluorobenzonitrile (1194-02-1,143234-87-1) + trans-1-(4-chloro-3-trifluoromethylphenyl)-3-(4-hydroxycyclohexyl)urea (1394011-78-9) → trans-1-(4-chloro-3-trifluoromethylphenyl)-3-[4-(4-cyanophenoxy)cyclohexyl]urea (1394011-86-9)

Guidance literature:

trans-1-(4-chloro-3-trifluoromethylphenyl)-3-(4-hydroxycyclohexyl)urea; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.166667h; Inert atmosphere;

4-fluorobenzonitrile; In mineral oil; at 0 - 20 ℃; Inert atmosphere;

upstream raw materials:

trans-4-aminocyclohexanol hydrochloride

4-chloro-3-(trifluoromethyl)phenyl isocyanate

Downstream raw materials:

trans-1-(4-chloro-3-trifluoromethylphenyl)-3-[4-(4-cyanophenoxy)cyclohexyl]urea

UC₂₂₈₈

trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}pyridine-2-carboxylic acid tert-butyl ester

trans-4-{4-[3-(4-chloro-3-trifluoromethylphenyl)ureido]cyclohexyloxy}benzoic acid