((E)-(1R,2S)-5-Benzyloxy-1-ethynyl-2-methyl-pent-3-enyloxy)-tert-butyl-dimethyl-silane

Base Information

Chemical Name:((E)-(1R,2S)-5-Benzyloxy-1-ethynyl-2-methyl-pent-3-enyloxy)-tert-butyl-dimethyl-silane
CAS No.:121896-39-7
Molecular Formula:C₂₁H₃₂O₂Si
Molecular Weight:344.569
Hs Code.:

Synonyms:((E)-(1R,2S)-5-Benzyloxy-1-ethynyl-2-methyl-pent-3-enyloxy)-tert-butyl-dimethyl-silane

Suppliers and Price of ((E)-(1R,2S)-5-Benzyloxy-1-ethynyl-2-methyl-pent-3-enyloxy)-tert-butyl-dimethyl-silane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ((E)-(1R,2S)-5-Benzyloxy-1-ethynyl-2-methyl-pent-3-enyloxy)-tert-butyl-dimethyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ((E)-(1R,2S)-5-Benzyloxy-1-ethynyl-2-methyl-pent-3-enyloxy)-tert-butyl-dimethyl-silane

There total 6 articles about ((E)-(1R,2S)-5-Benzyloxy-1-ethynyl-2-methyl-pent-3-enyloxy)-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 120448-41-1
(3R,4S)-(E)-7-benzyloxy-4-methylhept-5-en-1-yn-3-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 121896-39-7
((E)-(1R,2S)-5-Benzyloxy-1-ethynyl-2-methyl-pent-3-enyloxy)-tert-butyl-dimethyl-silane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 12h; Ambient temperature;
DOI:10.3987/COM-91-S80

Reference yield:

: 131101-47-8,135501-85-8,110339-27-0
(R)-5-Benzyloxy-4-hydroxy-2-pentyne

: 121896-39-7
((E)-(1R,2S)-5-Benzyloxy-1-ethynyl-2-methyl-pent-3-enyloxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Lindlar catalyst / ethyl acetate / Ambient temperature

2: 1.) KF-Al₂O₃; 2.) EtMgBr / 1.) CH₃CN, rt; 2.) Et₂O, 0 deg C

3: 90 percent / n-BuLi / tetrahydrofuran / -78 °C

4: n-Bu₄NF / tetrahydrofuran / Ambient temperature

5: 87 percent / imidazole / dimethylformamide / Ambient temperature

With 1H-imidazole; potassium fluoride on basic alumina; n-butyllithium; ethylmagnesium bromide; tetrabutyl ammonium fluoride; hydrogen; Lindlar's catalyst; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1246/cl.1988.2041

Reference yield:

: 111149-31-6
(3R,4S)-(E)-7-benzyloxy-4-methyl-1-trimethylsilylhept-5-en-1-yn-3-ol

: 121896-39-7
((E)-(1R,2S)-5-Benzyloxy-1-ethynyl-2-methyl-pent-3-enyloxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: n-Bu₄NF / tetrahydrofuran / Ambient temperature

2: 87 percent / imidazole / dimethylformamide / Ambient temperature

With 1H-imidazole; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1246/cl.1988.2041