methyl 3-[[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethyl]-(2-nitro-benzenesulfonyl)-amino]-propanoate

Base Information

Chemical Name:methyl 3-[[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethyl]-(2-nitro-benzenesulfonyl)-amino]-propanoate
CAS No.:1356864-71-5
Molecular Formula:C₁₉H₂₃N₃O₉S
Molecular Weight:469.472
Hs Code.:

Synonyms:methyl 3-[[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethyl]-(2-nitro-benzenesulfonyl)-amino]-propanoate

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Chemical Property of methyl 3-[[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethyl]-(2-nitro-benzenesulfonyl)-amino]-propanoate

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Technology Process of methyl 3-[[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethyl]-(2-nitro-benzenesulfonyl)-amino]-propanoate

There total 8 articles about methyl 3-[[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethyl]-(2-nitro-benzenesulfonyl)-amino]-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₁N₃O₉S

: 18107-18-1
diazomethyl-trimethyl-silane

: 1356864-71-5
methyl 3-[[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethyl]-(2-nitro-benzenesulfonyl)-amino]-propanoate

Guidance literature:: C₁₈H₂₁N₃O₉S; diazomethyl-trimethyl-silane; In methanol; hexane; at 5 ℃; for 1.5h;

With acetic acid; In methanol; hexane;

Reference yield:

: tert-butyl 3-[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethylamino]-propanoate

: 18107-18-1
diazomethyl-trimethyl-silane

: 1356864-70-4
methyl 3-[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethylamino]-propanoate

: 1356864-71-5
methyl 3-[[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethyl]-(2-nitro-benzenesulfonyl)-amino]-propanoate

Guidance literature:: With acetic acid; trifluoroacetic acid; In methanol; hexane; water; ethyl acetate;

Reference yield:

: 18226-11-4
N-(2-hydroxy-ethyl)-2-nitro-benzenesulfonamide

: 1356864-71-5
methyl 3-[[2-(2,6-bis-hydroxymethyl-pyridin-4-yloxy)-ethyl]-(2-nitro-benzenesulfonyl)-amino]-propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 40 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / -5 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 h / 60 °C

4: calcium chloride; sodium tetrahydroborate / ethanol / 20 °C

5: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

6: hexane; methanol / 1.5 h / 5 °C

With sodium tetrahydroborate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; calcium chloride; In methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;