methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-yl(methyl)carbamate

Base Information

Chemical Name:methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-yl(methyl)carbamate
CAS No.:1375182-85-6
Molecular Formula:C₁₉H₁₈FN₉O₂S
Molecular Weight:455.475
Hs Code.:

Synonyms:methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-yl(methyl)carbamate

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Chemical Property of methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-yl(methyl)carbamate

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Technology Process of methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-yl(methyl)carbamate

There total 7 articles about methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-yl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1375182-83-4
methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-ylcarbamate

: 74-88-4
methyl iodide

: 1375182-85-6
methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-yl(methyl)carbamate

Guidance literature:: methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-ylcarbamate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.333333h;

Reference yield:

: 1375183-34-8
1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboxamide

: 1375182-85-6
methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic anhydride; pyridine / 2.08 h / 0 - 20 °C

2.1: sodium methylate; methanol / 5 h / 20 °C

2.2: 17 h / 20 °C

3.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 26 h / 110 °C / sealed tube

4.1: sodium hydroxide; sodium dithionite / N,N-dimethyl-formamide / 2 h / 150 °C

5.1: pyridine / N,N-dimethyl-formamide / 3.5 h / 0 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

6.2: 0.33 h / 0 - 20 °C

With pyridine; methanol; sodium dithionite; sodium methylate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic anhydride; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1375183-36-0
1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carbonitrile

: 1375182-85-6
methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate; methanol / 5 h / 20 °C

1.2: 17 h / 20 °C

2.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 26 h / 110 °C / sealed tube

3.1: sodium hydroxide; sodium dithionite / N,N-dimethyl-formamide / 2 h / 150 °C

4.1: pyridine / N,N-dimethyl-formamide / 3.5 h / 0 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

5.2: 0.33 h / 0 - 20 °C

With pyridine; methanol; sodium dithionite; sodium methylate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;