methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-ylcarbamate

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Chemical Name:methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-ylcarbamate
CAS No.:1375182-83-4
Molecular Formula:C₁₈H₁₆FN₉O₂S
Molecular Weight:441.449
Hs Code.:

Synonyms:methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-ylcarbamate

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Chemical Property of methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-ylcarbamate

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Technology Process of methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-ylcarbamate

There total 6 articles about methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1375182-81-2
2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-4,5,6-triamine

: 79-22-1
methyl chloroformate

: 1375182-83-4
methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-ylcarbamate

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; at 0 ℃; for 3.5h;

Reference yield:

: 1375183-36-0
1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carbonitrile

: 1375182-83-4
methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate; methanol / 5 h / 20 °C

1.2: 17 h / 20 °C

2.1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 26 h / 110 °C / sealed tube

3.1: sodium hydroxide; sodium dithionite / N,N-dimethyl-formamide / 2 h / 150 °C

4.1: pyridine / N,N-dimethyl-formamide / 3.5 h / 0 °C

With pyridine; methanol; sodium dithionite; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1375183-37-1
1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboximidamide

: 1375182-83-4
methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)pyrimidin-5-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol / 26 h / 110 °C / sealed tube

2: sodium hydroxide; sodium dithionite / N,N-dimethyl-formamide / 2 h / 150 °C

3: pyridine / N,N-dimethyl-formamide / 3.5 h / 0 °C

With pyridine; sodium dithionite; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;