Dansyl-L-arginine

Base Information

• Chemical Name: Dansyl-L-arginine
• CAS No.: 28217-22-3
• Molecular Formula: C18H25 N5 O4 S
• Molecular Weight: 407.494
• Hs Code.: 2935009090
• European Community (EC) Number: 248-904-6
• Nikkaji Number: J250.676I
• Wikidata: Q27457040
• Mol file: 28217-22-3.mol

Synonyms:dansyl-L-arginine

Chemical Property of Dansyl-L-arginine

Chemical Property:

• Vapor Pressure: 8.06E-19mmHg at 25°C
• Boiling Point: 669.2°Cat760mmHg
• PKA: 3.22±0.21(Predicted)
• Flash Point: 358.5°C
• PSA: 156.99000
• Density: 1.39g/cm³
• LogP: 3.56320
• Storage Temp.: −20°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 407.16272547
• Heavy Atom Count: 28
• Complexity: 657

Purity/Quality:

99% ^*data from raw suppliers

α-Dansyl-L-arginine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)NC(CCCN=C(N)N)C(=O)O
• Isomeric SMILES: CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)N[C@@H](CCCN=C(N)N)C(=O)O

Technology Process of Dansyl-L-arginine

There total 3 articles about Dansyl-L-arginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

5-(dimethylamino)naphth-1-ylsulfonyl chloride (605-65-2) + L-arginine (74-79-3,157-06-2,7004-12-8,7200-25-1,25212-18-4) → Nα-dansyl-L-arginine (4307-78-2,28217-22-3,71869-46-0)

Guidance literature:

With potassium carbonate; In diethyl ether; water; for 48h; Ambient temperature;

DOI:10.1021/jm00182a003

Reference yield:

L-arginine (74-79-3,25212-18-4) + 5-(dimethylamino)naphth-1-ylsulfonyl chloride (605-65-2) → α-dansyl-L-arginine (28217-22-3)

Guidance literature:

With potassium carbonate; In water; benzene; at 60 ℃; for 3h;

DOI:10.1021/jm00186a003

Reference yield:

5-(dimethylamino)naphth-1-ylsulfonyl chloride (605-65-2) + D-arginine (74-79-3,157-06-2,7004-12-8,7200-25-1,25212-18-4) → 2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-5-guanidino-pentanoic acid (4307-78-2,28217-22-3,71869-46-0)

Guidance literature:

With potassium carbonate; In diethyl ether; water; for 48h; Ambient temperature;

DOI:10.1021/jm00182a003

upstream raw materials:

L-arginine

5-(dimethylamino)naphth-1-ylsulfonyl chloride

D-arginine

L-arginine

Downstream raw materials:

2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-5-guanidino-pentanoic acid methyl ester; hydrochloride

2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-5-guanidino-pentanoic acid tetrahydro-furan-2-ylmethyl ester; compound with toluene-4-sulfonic acid

N^α-dansyl-L-arginine methyl ester dihydrochloride

2-(5-Dimethylamino-naphthalene-1-sulfonylamino)-5-guanidino-pentanoic acid 2-ethyl-hexyl ester; compound with toluene-4-sulfonic acid