2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(3-hydroxypropyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide

Base Information

Chemical Name:2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(3-hydroxypropyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide
CAS No.:1361413-42-4
Molecular Formula:C₂₉H₂₈N₂O₅S₂
Molecular Weight:548.684
Hs Code.:

Synonyms:2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(3-hydroxypropyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide

Suppliers and Price of 2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(3-hydroxypropyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(3-hydroxypropyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(3-hydroxypropyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide

There total 10 articles about 2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(3-hydroxypropyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361414-40-5
3-(4-{[2-({[4-(ethylsulfonyl)phenyl]acetyl}amino)-4-phenyl-1,3-thiazol-5-yl]carbonyl}phenyl)propyl acetate

: 1361413-42-4
2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(3-hydroxypropyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide

Guidance literature:: 3-(4-{[2-({[4-(ethylsulfonyl)phenyl]acetyl}amino)-4-phenyl-1,3-thiazol-5-yl]carbonyl}phenyl)propyl acetate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: ethyl 2-(4-(ethylthio)phenyl)acetate

: 1361413-42-4
2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(3-hydroxypropyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2.1: sodium hydroxide; water / ethanol / 20 °C

2.2: pH 1

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C / Inert atmosphere

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C

With lithium hydroxide monohydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 122-72-5
3-phenylpropyl acetate

: 1361413-42-4
2-[4-(ethylsulfonyl)phenyl]-N-(5-{[4-(3-hydroxypropyl)phenyl]carbonyl}-4-phenyl-1,3-thiazol-2-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: aluminum (III) chloride / dichloromethane / 8 h / 0 °C / Inert atmosphere

2: bromine / diethyl ether / 1 h / 0 - 20 °C

3: N,N-dimethyl-formamide / 0.75 h / 85 °C / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C / Inert atmosphere

5: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 °C

With aluminum (III) chloride; lithium hydroxide monohydrate; water; bromine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;