N-{2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

Base Information

Chemical Name:N-{2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride
CAS No.:1200399-90-1
Molecular Formula:C₂₁H₂₀ClN₃OS*ClH
Molecular Weight:434.389
Hs Code.:

Synonyms:N-{2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

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Chemical Property of N-{2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

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Technology Process of N-{2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

There total 4 articles about N-{2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1200399-48-9
1,1-dimethylethyl 6-[({2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}amino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

: 1200399-90-1
N-{2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 4h;

Reference yield:

: 1200399-46-7
1,1-dimethylethyl {2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}carbamate

: 1200399-90-1
N-{2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethyl acetate / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 120 h / 20 °C

3: hydrogenchloride / ethyl acetate / 4 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; ethyl acetate;

Reference yield:

: 17518-48-8
4-chlorophenylthioacetamide

: 1200399-90-1
N-{2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}-1,2,3,4-tetrahydro-6-isoquinolinecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 4 h / Reflux

2: water; sodium hydroxide / ethanol / 1 h / Reflux

3: diphenyl phosphoryl azide; triethylamine / 3 h / Reflux; Inert atmosphere

4: hydrogenchloride / ethyl acetate / 20 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 120 h / 20 °C

6: hydrogenchloride / ethyl acetate / 4 h / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; dichloromethane; ethyl acetate;