1,1-dimethylethyl 6-[({2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}amino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 6-[({2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}amino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate
CAS No.:1200399-48-9
Molecular Formula:C₂₆H₂₈ClN₃O₃S
Molecular Weight:498.046
Hs Code.:

Synonyms:1,1-dimethylethyl 6-[({2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}amino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

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Chemical Property of 1,1-dimethylethyl 6-[({2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}amino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

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Technology Process of 1,1-dimethylethyl 6-[({2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}amino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

There total 3 articles about 1,1-dimethylethyl 6-[({2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}amino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-amine hydrochloride

: 170097-67-3
2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

: 1200399-48-9
1,1-dimethylethyl 6-[({2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}amino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 120h;

Reference yield:

: 1200399-46-7
1,1-dimethylethyl {2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}carbamate

: 1200399-48-9
1,1-dimethylethyl 6-[({2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}amino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 120 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; ethyl acetate;

Reference yield:

: 17518-48-8
4-chlorophenylthioacetamide

: 1200399-48-9
1,1-dimethylethyl 6-[({2-[(4-chlorophenyl)methyl]-4-methyl-1,3-thiazol-5-yl}amino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 4 h / Reflux

2: water; sodium hydroxide / ethanol / 1 h / Reflux

3: diphenyl phosphoryl azide; triethylamine / 3 h / Reflux; Inert atmosphere

4: hydrogenchloride / ethyl acetate / 20 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 120 h / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In ethanol; dichloromethane; ethyl acetate;