2-(2-Methoxy-6-methyl-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

Base Information

Chemical Name:2-(2-Methoxy-6-methyl-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole
CAS No.:1268726-45-9
Molecular Formula:C₁₄H₁₆F₃NO₂
Molecular Weight:287.282
Hs Code.:

Synonyms:2-(2-Methoxy-6-methyl-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

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Chemical Property of 2-(2-Methoxy-6-methyl-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

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Technology Process of 2-(2-Methoxy-6-methyl-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

There total 10 articles about 2-(2-Methoxy-6-methyl-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.4%

: 1268726-43-7
2-(2,6-dimethoxy-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

: 75-16-1
methylmagnesium bromide

: 1268726-45-9
2-(2-Methoxy-6-methyl-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

: 1268726-44-8
2-(2,6-dimethyl-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: 2-(2,6-dimethoxy-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 - 70 ℃; for 24h; Molecular sieve;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;

Reference yield: 31.2%

: 1268726-43-7
2-(2,6-dimethoxy-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

: 1268726-45-9
2-(2-Methoxy-6-methyl-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

: 1268726-44-8
2-(2,6-dimethyl-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: With methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 - 70 ℃;

Reference yield:

: 1236303-15-3
2,6-Dimethoxy-4-trifluoromethyl-benzoic acid

: 1268726-45-9
2-(2-Methoxy-6-methyl-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

: 1268726-44-8
2-(2,6-dimethyl-4-trifluoromethyl-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide; thionyl chloride / toluene / 3 h / 20 - 85 °C / Inert atmosphere

2: dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3: thionyl chloride / dichloromethane / 10 - 20 °C

4: methylmagnesium bromide / diethyl ether; tetrahydrofuran / 0 - 70 °C

With thionyl chloride; methylmagnesium bromide; N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;