Technology Process of ethyl 12-chloro-8-[(2,4-dimethoxyphenyl)methyl]-9-oxo-2,4, 8-triazatricyclo[8 .4.0.02,6]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate
There total 5 articles about ethyl 12-chloro-8-[(2,4-dimethoxyphenyl)methyl]-9-oxo-2,4, 8-triazatricyclo[8 .4.0.02,6]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
7-chloro-4-[(2,4-dimethoxyphenyl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2,5-dione;
With
potassium tert-butylate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at -20 ℃;
for 0.333333h;
With
diethyl chlorophosphate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at -20 - 5 ℃;
for 3h;
Ethyl isocyanoacetate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at -78 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: para-xylene / 3 h / 140 °C
2.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 0.33 h / -20 °C
2.2: 3 h / -20 - 5 °C
2.3: -78 - 20 °C
With
potassium tert-butylate;
In
tetrahydrofuran; para-xylene; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2.1: sodium hydroxide; water / methanol / 2 h / 20 °C
3.1: para-xylene / 3 h / 140 °C
4.1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 0.33 h / -20 °C
4.2: 3 h / -20 - 5 °C
4.3: -78 - 20 °C
With
potassium tert-butylate; water; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; para-xylene; N,N-dimethyl-formamide;
