(S)-2,2,2-trifluoro-N-(2-hydroxy-3-(trityloxy)propyl)-N-methylacetamide

Base Information

Chemical Name:(S)-2,2,2-trifluoro-N-(2-hydroxy-3-(trityloxy)propyl)-N-methylacetamide
CAS No.:952507-62-9
Molecular Formula:C₂₅H₂₄F₃NO₃
Molecular Weight:443.466
Hs Code.:

Synonyms:(S)-2,2,2-trifluoro-N-(2-hydroxy-3-(trityloxy)propyl)-N-methylacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2,2,2-trifluoro-N-(2-hydroxy-3-(trityloxy)propyl)-N-methylacetamide

Chemical Property:

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Technology Process of (S)-2,2,2-trifluoro-N-(2-hydroxy-3-(trityloxy)propyl)-N-methylacetamide

There total 3 articles about (S)-2,2,2-trifluoro-N-(2-hydroxy-3-(trityloxy)propyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 952507-58-3
(S)-1-(methylamino)-3-(trityloxy)propan-2-ol

: 407-25-0
trifluoroacetic anhydride

: 952507-62-9
(S)-2,2,2-trifluoro-N-(2-hydroxy-3-(trityloxy)propyl)-N-methylacetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -20 ℃; for 0.666667h;
DOI:10.1016/j.tet.2007.07.044

Reference yield:

: 637343-84-1
(S)-3-methyl-5-(trityloxymethyl)oxazolidin-2-one

: 952507-62-9
(S)-2,2,2-trifluoro-N-(2-hydroxy-3-(trityloxy)propyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / lithium hydroxide; sodium hydroxide / ethanol; tetrahydrofuran; H₂O / 48 h / Heating

2: 72 percent / diisopropylethylamine / tetrahydrofuran / 0.67 h / -20 °C

With lithium hydroxide; sodium hydroxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.tet.2007.07.044

Reference yield:

: 330555-60-7
(S)-5-triphenylmethoxymethyl-1,3-oxazolidin-2-one

: 952507-62-9
(S)-2,2,2-trifluoro-N-(2-hydroxy-3-(trityloxy)propyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butoxide / tetrahydrofuran / 1 h / 0 °C

1.2: 88 percent / tetrahydrofuran / 2 h / 20 °C

2.1: 84 percent / lithium hydroxide; sodium hydroxide / ethanol; tetrahydrofuran; H₂O / 48 h / Heating

3.1: 72 percent / diisopropylethylamine / tetrahydrofuran / 0.67 h / -20 °C

With lithium hydroxide; sodium hydroxide; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.tet.2007.07.044