330555-60-7

Upstream product

• 113240-54-3 (3S)-3-hydroxy-4-O-triphenylmethyloxybutanoic acid 
• 76-83-5 trityl chloride 
• 330555-58-3 (S)-3-hydroxy-4-triphenylmethoxybutanamide 

Downstream Products

• 7517-99-9 (S)-5-(hydroxymethyl)-1,3-oxazolidin-2-one 
• 165967-44-2 (S)-1-amino-3-(trityloxy)propan-2-ol 
• 637343-47-6 (S)-N-ethyl 5-hydroxymethyl-2-oxazolidinone 
• 637343-80-7 C₂₈H₃₁NO₅ 
• 637343-45-4 (S)-3-(2,5-dimethoxyphenacyl)-5-trityloxymethyl-2-oxazolidinone 
• 637343-44-3 (S)-3-(2-nitrophenyl)-5-trityloxymethy-2-oxazolidinone 
• 637343-48-7 n-isopropyl-5-trityloxymethyl-2-oxazolidinone 
• 952507-65-2 (S)-1-(2,2,2-trifluoro-N-methylacetamido)-3-(trityloxy)propan-2-yl-methanesulfonate 
• 952507-64-1 (S)-1-(2,2,2-trifluoroacetamido)-3-(trityloxy)propan-2-yl-methanesulfonate 
• 952507-62-9 (S)-2,2,2-trifluoro-N-(2-hydroxy-3-(trityloxy)propyl)-N-methylacetamide 
• 952507-60-7 (S)-2,2,2-trifluoro-N-(2-hydroxy-3-(trityloxy)propyl)acetamide 
• 952507-58-3 (S)-1-(methylamino)-3-(trityloxy)propan-2-ol 
• 952507-67-4 (R)-2-(trifluoromethyl)-5-(trityloxymethyl)-oxazoline 
• 637343-84-1 (S)-3-methyl-5-(trityloxymethyl)oxazolidin-2-one 

Relevant academic research and scientific papers

Synthesis of homochiral tetrahydropteridines

A synthesis of protected homochiral tetrahydropteridines from (2S)-malic acid has been developed. This presents methodology for the synthesis of reduced pteridine coenzymes and pharmaceuticals.

Lipase-mediated resolution of 3-hydroxy-4-trityloxybutanenitrile: synthesis of 2-amino alcohols, oxazolidinones and GABOB

Lipase-mediated kinetic resolution of 3-hydroxy-4-trityloxybutanenitrile gave the (S)-alcohol and (R)-acetate in good yields and high enantioselectivities. The resolution using Pseudomonas cepacia lipase (Burkholderia cepacia) immobilized on modified cera

PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF

A process for preparing N-(substituted)-C-- (substituted methyl)-oxazolidinones, C-(substituted methyl)-oxazolidinones, and N-(substituted)-C-- (substituted ethyl)-oxazolidinones, preferably chiral, from optically active C-(protected oxymethyl)- oxazolidi

A simple three-step method for preparing homochiral 5-trityloxymethyl-2-oxazolidinones from optically active 3-hydroxy-γ-butyrolactones

A simple high-yield three-step route to O-tritylated optically active 5-hydroxymethyl oxazolidinones from optically active 3-hydroxy-γ-butyrolactones is described. The key intermediate is the 4-O-trityl ether of homochiral 3,4-dihydroxybutyramide, which is obtained in quantitative yield from 3-hydroxy-γ-butyrolactone by treatment with ammonia. It is readily transformed to the oxazolidinone by Hoffmann rearrangement in a two-phase system. The carbonyl group in the oxazolidinone is derived from C-1 of the amide, and a separate carbonylation reaction is not required. Oxazolidinones are key compounds in drug synthesis especially in the areas of antibacterials and behavior disorder therapy.