(2S,3R)-3-[(3R,4S)-4-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoyloxy]-2-methyl-decanoic acid benzyl ester

Base Information

Chemical Name:(2S,3R)-3-[(3R,4S)-4-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoyloxy]-2-methyl-decanoic acid benzyl ester
CAS No.:185208-61-1
Molecular Formula:C₄₁H₆₅NO₇Si
Molecular Weight:712.055
Hs Code.:

(2S,3R)-3-[(3R,4S)-4-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoyloxy]-2-methyl-decanoic acid benzyl ester

Synonyms:(2S,3R)-3-[(3R,4S)-4-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoyloxy]-2-methyl-decanoic acid benzyl ester

Suppliers and Price of (2S,3R)-3-[(3R,4S)-4-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoyloxy]-2-methyl-decanoic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R)-3-[(3R,4S)-4-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoyloxy]-2-methyl-decanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R)-3-[(3R,4S)-4-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoyloxy]-2-methyl-decanoic acid benzyl ester

There total 26 articles about (2S,3R)-3-[(3R,4S)-4-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoyloxy]-2-methyl-decanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 178113-54-7
benzyl (2S,3R)-3-hydroxy-2-methyldecanoate

: 178113-66-1
(3R,4S)-4-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoic acid

: 185208-61-1
(2S,3R)-3-[(3R,4S)-4-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoyloxy]-2-methyl-decanoic acid benzyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 40 ℃; for 8h;

Reference yield:

: 101249-11-0,145362-91-0,145362-93-2
(2S,3R)-3-Hydroxy-2-methyl-pent-4-enoic acid methyl ester

: 185208-61-1
(2S,3R)-3-[(3R,4S)-4-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoyloxy]-2-methyl-decanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 42 percent / Candida antarctica (fraction B) / toluene / 60 h / 20 °C

2: 85 percent / K₂CO₃ / methanol / 1 h / 20 °C

3: 71 percent / chiral ruthenium complex / CH₂Cl₂ / 12 h / 20 °C

4: 82 percent / H₂ / Pd/C / ethanol / 2 h / 760 Torr

5: aq. NaOH / methanol / 5 h / 20 °C

6: Cs₂CO₃ / dimethylformamide / 12 h / 20 °C

7: 89 percent / EDCI; DMAP / CH₂Cl₂ / 8 h / 40 °C

With dmap; sodium hydroxide; Candida antarctica (fraction B); hydrogen; potassium carbonate; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 261785-50-6
(2S,3R)-3-hydroxy-2-methyl-4-pentenoic acid methyl ester

: 185208-61-1
(2S,3R)-3-[(3R,4S)-4-(tert-Butoxycarbonyl-methyl-amino)-3-(tert-butyl-dimethyl-silanyloxy)-5-phenyl-pentanoyloxy]-2-methyl-decanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / chiral ruthenium complex / CH₂Cl₂ / 12 h / 20 °C

2: 82 percent / H₂ / Pd/C / ethanol / 2 h / 760 Torr

3: aq. NaOH / methanol / 5 h / 20 °C

4: Cs₂CO₃ / dimethylformamide / 12 h / 20 °C

5: 89 percent / EDCI; DMAP / CH₂Cl₂ / 8 h / 40 °C

With dmap; sodium hydroxide; hydrogen; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;