3-(3',4'-dimethoxyphenyl)-1-(2'',4'',6'-trimethoxyphenyl)prop-2-yn-1-one

Base Information

• Chemical Name: 3-(3',4'-dimethoxyphenyl)-1-(2'',4'',6'-trimethoxyphenyl)prop-2-yn-1-one
• CAS No.: 1312774-65-4
• Molecular Formula: C₂₀H₂₀O₆
• Molecular Weight: 356.375
• Mol file: 1312774-65-4.mol

Synonyms:3-(3',4'-dimethoxyphenyl)-1-(2'',4'',6'-trimethoxyphenyl)prop-2-yn-1-one

Chemical Property of 3-(3',4'-dimethoxyphenyl)-1-(2'',4'',6'-trimethoxyphenyl)prop-2-yn-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3',4'-dimethoxyphenyl)-1-(2'',4'',6'-trimethoxyphenyl)prop-2-yn-1-one

There total 1 articles about 3-(3',4'-dimethoxyphenyl)-1-(2'',4'',6'-trimethoxyphenyl)prop-2-yn-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

carbon monoxide (201230-82-2) + 4-(bromoethynyl)-1,2-dimethoxybenzene (1206482-93-0) + 2-iodo-1,3,5-trimethoxybenzene (2510-49-8) → 3-(3',4'-dimethoxyphenyl)-1-(2'',4'',6'-trimethoxyphenyl)prop-2-yn-1-one (1312774-65-4)

Guidance literature:

2-iodo-1,3,5-trimethoxybenzene; With n-butyllithium; zinc dibromide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

carbon monoxide; 4-(bromoethynyl)-1,2-dimethoxybenzene; With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; triphenylphosphine; lithium bromide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; hexane; at 80 ℃; for 24h; under 8791.75 Torr; Pressure reactor;

DOI:10.1016/j.tet.2011.03.074

Reference yield: 37.0%

3-(3',4'-dimethoxyphenyl)-1-(2'',4'',6'-trimethoxyphenyl)prop-2-yn-1-one (1312774-65-4) → 3-(3',4'-dimethoxyphenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-yn-1-one (1064710-43-5)

Guidance literature:

With methanol; boron tribromide; In dichloromethane; at -78 ℃; for 0.0166667h; Inert atmosphere;

DOI:10.1016/j.tet.2011.03.074

Reference yield:

3-(3',4'-dimethoxyphenyl)-1-(2'',4'',6'-trimethoxyphenyl)prop-2-yn-1-one (1312774-65-4) → 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4H-chromen-4-one (855-97-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; boron tribromide / dichloromethane / 0.02 h / -78 °C / Inert atmosphere

2: caesium carbonate / acetone / 0.17 h / 20 °C

With methanol; boron tribromide; caesium carbonate; In dichloromethane; acetone;

DOI:10.1016/j.tet.2011.03.074

upstream raw materials:

carbon monoxide

4-(bromoethynyl)-1,2-dimethoxybenzene

2-iodo-1,3,5-trimethoxybenzene

Downstream raw materials:

3-(3',4'-dimethoxyphenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-yn-1-one

2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4H-chromen-4-one