3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutylamine

Base Information

Chemical Name:3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutylamine
CAS No.:606929-59-3
Molecular Formula:C₂₁H₂₁F₆NO
Molecular Weight:417.394
Hs Code.:

Synonyms:3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutylamine

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Chemical Property of 3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutylamine

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Technology Process of 3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutylamine

There total 7 articles about 3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 606929-58-2
Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amine

: 606929-59-3
3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutylamine

Guidance literature:: With hydrogen; palladium on activated charcoal; at 20 ℃; for 24h; under 760 Torr;
DOI:10.1016/j.bmcl.2006.04.031

Reference yield:

: 530441-99-7
2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethanone

: 606929-59-3
3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / NaNH₂ / tetrahydrofuran / 24 h / 20 °C

2: 86 percent / Zn-Cu / diethyl ether; 1,2-dimethoxy-ethane / 120 h / Heating

3: Zn dust; AcOH / 48 h / 20 °C

4: 94 percent / NaBH(OAc)3 / 24 h / 20 °C

5: 81 percent / H₂ / Pd/C / 24 h / 20 °C / 760 Torr

With hydrogen; sodium tris(acetoxy)borohydride; copper; sodium amide; acetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; 1: Wittig reaction;
DOI:10.1016/j.bmcl.2006.04.031

Reference yield:

: 606137-78-4
1-[(R)-1-(2-Phenyl-allyloxy)-ethyl]-3,5-bis-trifluoromethyl-benzene

: 606929-59-3
3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / Zn-Cu / diethyl ether; 1,2-dimethoxy-ethane / 120 h / Heating

2: Zn dust; AcOH / 48 h / 20 °C

3: 94 percent / NaBH(OAc)3 / 24 h / 20 °C

4: 81 percent / H₂ / Pd/C / 24 h / 20 °C / 760 Torr

With hydrogen; sodium tris(acetoxy)borohydride; copper; acetic acid; zinc; palladium on activated charcoal; In 1,2-dimethoxyethane; diethyl ether;
DOI:10.1016/j.bmcl.2006.04.031