606929-58-2

Upstream product

• 62861-51-2 phenacyl trifluoromethanesulfonate 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 530441-99-7 2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethanone 
• 606137-09-1 3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutanone 
• 100-46-9 benzylamine 
• 903877-33-8 3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2,2-dichloro-3-phenyl-cyclobutanone 
• 606137-78-4 1-[(R)-1-(2-Phenyl-allyloxy)-ethyl]-3,5-bis-trifluoromethyl-benzene 

Downstream Products

• 606929-61-7 5-[(Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amino)-methyl]-2,4-dihydro-[1,2,4]triazol-3-one 
• 606929-59-3 3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutylamine 

Relevant academic research and scientific papers

Cyclobutane derivatives as potent NK1 selective antagonists

A series of novel cyclobutane derivatives as potent and selective NK1 receptor antagonists is described. Several compounds in this series exhibited high in vitro binding affinity (Ki {less-than or slanted equal to} 1 nM), and potent