Technology Process of (R)-tert-butyl 1-methoxy-3-(3-oxo-4-(m-tolylamino)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)propan-2-ylcarbamate
There total 12 articles about (R)-tert-butyl 1-methoxy-3-(3-oxo-4-(m-tolylamino)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)propan-2-ylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-methoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate;
With
hydrogen; acetic acid;
platinum(IV) oxide;
In
dichloromethane;
at 20 ℃;
for 16h;
under 760.051 Torr;
With
potassium carbonate;
In
dichloromethane;
at 20 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride; methanol / tetrahydrofuran; mineral oil / 1 h / 20 °C
1.2: 38 h / 20 °C
1.3: pH 2
2.1: 4-methyl-morpholine / tetrahydrofuran / 0.25 h / -15 °C
2.2: 0.5 h
3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C
4.1: sodium azide / N,N-dimethyl-formamide / 4 h / 75 °C
5.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 760.05 Torr
6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C
7.1: hydrogen; acetic acid / platinum(IV) oxide / dichloromethane / 16 h / 20 °C / 760.05 Torr
7.2: 12 h / 20 °C
With
4-methyl-morpholine; methanol; sodium azide; hydrogen; sodium hydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine;
platinum(IV) oxide; palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C
1.2: 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C
3.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 100 °C / 760.05 Torr / Inert atmosphere
4.1: triethylamine / tetrahydrofuran / 72 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C
6.1: hydrogen; acetic acid / platinum(IV) oxide / dichloromethane / 16 h / 20 °C / 760.05 Torr
6.2: 12 h / 20 °C
With
n-butyllithium; hydrogen; potassium carbonate; acetic acid; triethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine;
platinum(IV) oxide; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
