(R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-methoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate

Base Information

Chemical Name:(R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-methoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate
CAS No.:1312693-01-8
Molecular Formula:C₂₄H₃₁N₅O₅
Molecular Weight:469.541
Hs Code.:

Synonyms:(R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-methoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate

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Chemical Property of (R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-methoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate

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Technology Process of (R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-methoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate

There total 10 articles about (R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-methoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312690-83-7
methyl 6-chloro-4-cyano-2-(m-tolylamino)nicotinate

: 1194973-97-1
(R)-tert-butyl (1-amino-3-methoxypropan-2-yl)carbamate

: 1312693-01-8
(R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-methoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 1312693-01-8
(R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-methoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride; methanol / tetrahydrofuran; mineral oil / 1 h / 20 °C

1.2: 38 h / 20 °C

1.3: pH 2

2.1: 4-methyl-morpholine / tetrahydrofuran / 0.25 h / -15 °C

2.2: 0.5 h

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4.1: sodium azide / N,N-dimethyl-formamide / 4 h / 75 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 760.05 Torr

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With 4-methyl-morpholine; methanol; sodium azide; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 51293-47-1
N-tert-butoxycarbonyl-(S)-O-methyl-serin

: 1312693-01-8
(R)-methyl 6-(2-(tert-butoxycarbonylamino)-3-methoxypropylamino)-4-cyano-2-(m-tolylamino)nicotinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-methyl-morpholine / tetrahydrofuran / 0.25 h / -15 °C

1.2: 0.5 h

2.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3.1: sodium azide / N,N-dimethyl-formamide / 4 h / 75 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 760.05 Torr

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With 4-methyl-morpholine; sodium azide; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;