{[(2-{[1-(4-tert-butyl-2-chlorophenyl)piperidin-4-yl]methyl}-5-hydroxy-6-methylpyrimidin-4-yl)carbonyl]amino}acetic acid

Base Information

Chemical Name:{[(2-{[1-(4-tert-butyl-2-chlorophenyl)piperidin-4-yl]methyl}-5-hydroxy-6-methylpyrimidin-4-yl)carbonyl]amino}acetic acid
CAS No.:1192162-23-4
Molecular Formula:C₂₄H₃₁ClN₄O₄
Molecular Weight:474.988
Hs Code.:

Synonyms:{[(2-{[1-(4-tert-butyl-2-chlorophenyl)piperidin-4-yl]methyl}-5-hydroxy-6-methylpyrimidin-4-yl)carbonyl]amino}acetic acid

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Chemical Property of {[(2-{[1-(4-tert-butyl-2-chlorophenyl)piperidin-4-yl]methyl}-5-hydroxy-6-methylpyrimidin-4-yl)carbonyl]amino}acetic acid

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Technology Process of {[(2-{[1-(4-tert-butyl-2-chlorophenyl)piperidin-4-yl]methyl}-5-hydroxy-6-methylpyrimidin-4-yl)carbonyl]amino}acetic acid

There total 9 articles about {[(2-{[1-(4-tert-butyl-2-chlorophenyl)piperidin-4-yl]methyl}-5-hydroxy-6-methylpyrimidin-4-yl)carbonyl]amino}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1192161-74-2
{[(2-{[1-(4-tert-butylphenyl)piperidin-4-yl]methyl}-5-hydroxy-6-methylpyrimidin-4-yl)carbonyl]amino}acetic acid

: 1192162-23-4
{[(2-{[1-(4-tert-butyl-2-chlorophenyl)piperidin-4-yl]methyl}-5-hydroxy-6-methylpyrimidin-4-yl)carbonyl]amino}acetic acid

Guidance literature:: With hydrogenchloride; sodium chlorite; sodium sulfamate; In tetrahydrofuran; water; at 3 ℃; for 2h;

Reference yield:

: 1192164-05-8
tert-butyl 5-(benzyloxy)-2-{[1-(4-tert-butylphenyl)piperidin-4-yl]methyl}-6-methylpyrimidine-4-carboxylate

: 1192162-23-4
{[(2-{[1-(4-tert-butyl-2-chlorophenyl)piperidin-4-yl]methyl}-5-hydroxy-6-methylpyrimidin-4-yl)carbonyl]amino}acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 60 °C

1.2: 20 °C

2.1: 4-methyl-morpholine / tetrahydrofuran; ethanol / 0.08 h / 20 °C

2.2: 12 h / 20 °C

3.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 2.5 h / 20 °C

4.1: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

5.1: hydrogenchloride; sodium chlorite; sodium sulfamate / tetrahydrofuran; water / 2 h / 3 °C

With 4-methyl-morpholine; hydrogenchloride; sodium chlorite; sodium sulfamate; water; hydrogen; sodium hydroxide; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate;

Reference yield:

: 1192164-02-5
tert-butyl 5-(benzyloxy)-2-{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}-6-methylpyrimidine-4-carboxylate

: 1192162-23-4
{[(2-{[1-(4-tert-butyl-2-chlorophenyl)piperidin-4-yl]methyl}-5-hydroxy-6-methylpyrimidin-4-yl)carbonyl]amino}acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 8 h / Inert atmosphere; Reflux

3.1: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 60 °C

3.2: 20 °C

4.1: 4-methyl-morpholine / tetrahydrofuran; ethanol / 0.08 h / 20 °C

4.2: 12 h / 20 °C

5.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 2.5 h / 20 °C

6.1: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

7.1: hydrogenchloride; sodium chlorite; sodium sulfamate / tetrahydrofuran; water / 2 h / 3 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 4-methyl-morpholine; hydrogenchloride; sodium chlorite; sodium sulfamate; water; hydrogen; sodium hydroxide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; toluene;