[(1S,4S)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopent-2-en-1-yl] benzoate

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Chemical Name:[(1S,4S)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopent-2-en-1-yl] benzoate
CAS No.:1370007-78-5
Molecular Formula:C₃₅H₃₂N₄O₃
Molecular Weight:556.664
Hs Code.:

Synonyms:[(1S,4S)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopent-2-en-1-yl] benzoate

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Chemical Property of [(1S,4S)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopent-2-en-1-yl] benzoate

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Technology Process of [(1S,4S)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopent-2-en-1-yl] benzoate

There total 10 articles about [(1S,4S)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopent-2-en-1-yl] benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1392515-06-8
(1R,4S)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopent-2-en-1-ol

: 65-85-0,8013-63-6
benzoic acid

: 1370007-78-5
[(1S,4S)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopent-2-en-1-yl] benzoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; ethyl acetate; toluene; at 20 ℃; for 1h;

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 1370007-78-5
[(1S,4S)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopent-2-en-1-yl] benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 0.5 h / -40 - 20 °C

1.2: 24.5 h / -78 - 4 °C

1.3: 4 h

2.1: N-Methyldicyclohexylamine / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 60 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 0.5 h / -78 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 75 °C

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; hexane; ethyl acetate; toluene / 1 h / 20 °C

With N-Methyldicyclohexylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; hexane; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 628733-99-3
ethyl 1-amino-1H-pyrrole-2-carboxylate

: 1370007-78-5
[(1S,4S)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopent-2-en-1-yl] benzoate

Guidance literature:: Multi-step reaction with 8 steps

1: 1 h / 200 °C / Microwave irradiation

2: N-Bromosuccinimide; trifluoroacetic acid / dichloromethane / 1.25 h / 0 °C

3: trichlorophosphate / 2 h / 110 °C

4: tetrahydrofuran / 16 h / 20 °C

5: N-Methyldicyclohexylamine / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 60 °C / Inert atmosphere

6: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 0.5 h / -78 - 20 °C

7: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 75 °C

8: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; hexane; ethyl acetate; toluene / 1 h / 20 °C

With N-Bromosuccinimide; N-Methyldicyclohexylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; trichlorophosphate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; ethyl acetate; toluene;