[(1S,2R,4R)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopentyl] benzoate

Base Information

Chemical Name:[(1S,2R,4R)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopentyl] benzoate
CAS No.:1370007-80-9
Molecular Formula:C₃₅H₃₄N₄O₃
Molecular Weight:558.68
Hs Code.:

Synonyms:[(1S,2R,4R)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopentyl] benzoate

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Chemical Property of [(1S,2R,4R)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopentyl] benzoate

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Technology Process of [(1S,2R,4R)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopentyl] benzoate

There total 12 articles about [(1S,2R,4R)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopentyl] benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370007-78-5
[(1S,4S)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopent-2-en-1-yl] benzoate

: 1370007-80-9
[(1S,2R,4R)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopentyl] benzoate

: 1370007-82-1
[(1S,2S,4R)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopentyl] benzoate

Guidance literature:: With hydrogen; 10% Pd/C; In methanol; for 1h; under 2311.54 Torr;

Reference yield:

: 159326-71-3
pyrrolo[1,2-f][1,2,4]triazin-4-ol

: 1370007-80-9
[(1S,2R,4R)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopentyl] benzoate

: 1370007-82-1
[(1S,2S,4R)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopentyl] benzoate

Guidance literature:: Multi-step reaction with 8 steps

1: N-Bromosuccinimide; trifluoroacetic acid / dichloromethane / 1.25 h / 0 °C

2: trichlorophosphate / 2 h / 110 °C

3: tetrahydrofuran / 16 h / 20 °C

4: N-Methyldicyclohexylamine / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 60 °C / Inert atmosphere

5: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 0.5 h / -78 - 20 °C

6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 75 °C

7: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; hexane; ethyl acetate; toluene / 1 h / 20 °C

8: hydrogen / 10% Pd/C / methanol / 1 h / 2311.54 Torr

With N-Bromosuccinimide; N-Methyldicyclohexylamine; hydrogen; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; trichlorophosphate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 10% Pd/C; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; ethyl acetate; toluene;

Reference yield:

: 1269667-51-7
7-bromo-4-chloropyrrolo[2,1-f][1,2,4]triazine

: 1370007-80-9
[(1S,2R,4R)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopentyl] benzoate

: 1370007-82-1
[(1S,2S,4R)-2-(benzyloxymethyl)-4-[4-[[(1S)-indan-1-yl]amino]pyrrolo[2,1-f][1,2,4]triazin-7-yl]cyclopentyl] benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 16 h / 20 °C

2: N-Methyldicyclohexylamine / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 60 °C / Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 0.5 h / -78 - 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 75 °C

5: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; hexane; ethyl acetate; toluene / 1 h / 20 °C

6: hydrogen / 10% Pd/C / methanol / 1 h / 2311.54 Torr

With N-Methyldicyclohexylamine; hydrogen; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 10% Pd/C; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; ethyl acetate; toluene;