2-Methyl-6-o-tolylsulfanylmethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Base Information

• Chemical Name: 2-Methyl-6-o-tolylsulfanylmethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester
• CAS No.: 134968-24-4
• Molecular Formula: C₂₇H₂₈F₃NO₄S
• Molecular Weight: 519.585

Synonyms:2-Methyl-6-o-tolylsulfanylmethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Chemical Property of 2-Methyl-6-o-tolylsulfanylmethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methyl-6-o-tolylsulfanylmethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

There total 3 articles about 2-Methyl-6-o-tolylsulfanylmethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (2-chloroaceto)acetate (638-07-3) → 2-Methyl-6-o-tolylsulfanylmethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (134968-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / 4 h

2: ethanol / 18 h / Heating

With triethylamine; In ethanol;

DOI:10.1021/jm00111a047

Reference yield:

2-thiocresol (137-06-4) → 2-Methyl-6-o-tolylsulfanylmethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (134968-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / 4 h

2: ethanol / 18 h / Heating

With triethylamine; In ethanol;

DOI:10.1021/jm00111a047

Reference yield:

2-Trifluoromethylbenzaldehyde (447-61-0) + ethyl 4-(2-methylphenylthio)-3-oxobutanoate (83821-43-6) + ethyl (E)-3-aminobut-2-enoate (41867-20-3) → 2-Methyl-6-o-tolylsulfanylmethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester (134968-24-4) + (3S,4R)-6-Methyl-2-[1-o-tolylsulfanyl-meth-(Z)-ylidene]-4-(2-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid diethyl ester (134968-34-6)

Guidance literature:

In ethanol; for 18h; Yield given. Yields of byproduct given; Heating;

DOI:10.1021/jm00111a047

upstream raw materials:

2-Trifluoromethylbenzaldehyde

ethyl 4-(2-methylphenylthio)-3-oxobutanoate

ethyl (E)-3-aminobut-2-enoate

ethyl (2-chloroaceto)acetate

Downstream raw materials:

2-Methyl-6-(toluene-2-sulfinylmethyl)-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 134968-24-4 2-Methyl-6-o-tolylsulfanylmethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send