(3R)-N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide formate salt

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Chemical Name:(3R)-N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide formate salt
CAS No.:1240517-82-1
Molecular Formula:CH₂O₂*C₂₆H₂₈ClN₅O₅S₂
Molecular Weight:636.149
Hs Code.:

Synonyms:(3R)-N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide formate salt

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Chemical Property of (3R)-N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide formate salt

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Technology Process of (3R)-N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide formate salt

There total 1 articles about (3R)-N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide formate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 869681-70-9
(R)-morpholine-3,4-dicarboxylic acid 4-tert-butyl ester

: 64-18-6
formic acid

: 1240518-68-6
N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(1-hydroxyethyl)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide

: 1240517-82-1
(3R)-N-[(3-{[3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-(1-hydroxyethyl)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide formate salt

Guidance literature:: (R)-morpholine-3,4-dicarboxylic acid 4-tert-butyl ester; N-[1-{[3-(aminomethyl)phenyl]methyl}-4-(1-hydroxyethyl)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 1h;

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 0.5h;

formic acid; In methanol; water; dimethyl sulfoxide; acetonitrile;