(S)-[4-(4-aminomethyl-phenoxy)-phenyl]-tert-butoxycarbonylamino-acetic acid cyclopentyl ester

Base Information

Chemical Name:(S)-[4-(4-aminomethyl-phenoxy)-phenyl]-tert-butoxycarbonylamino-acetic acid cyclopentyl ester
CAS No.:914452-63-4
Molecular Formula:C₂₅H₃₂N₂O₅
Molecular Weight:440.539
Hs Code.:

Synonyms:(S)-[4-(4-aminomethyl-phenoxy)-phenyl]-tert-butoxycarbonylamino-acetic acid cyclopentyl ester

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Chemical Property of (S)-[4-(4-aminomethyl-phenoxy)-phenyl]-tert-butoxycarbonylamino-acetic acid cyclopentyl ester

Chemical Property:

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Technology Process of (S)-[4-(4-aminomethyl-phenoxy)-phenyl]-tert-butoxycarbonylamino-acetic acid cyclopentyl ester

There total 7 articles about (S)-[4-(4-aminomethyl-phenoxy)-phenyl]-tert-butoxycarbonylamino-acetic acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 914452-62-3
{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-phenyl}-(S)-tert-butoxycarbonylamino-acetic acid cyclopentyl ester

: 914452-63-4
(S)-[4-(4-aminomethyl-phenoxy)-phenyl]-tert-butoxycarbonylamino-acetic acid cyclopentyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate;

Reference yield:

: benzyl N-[(4-bromophenyl)methyl]carbamate

: 914452-63-4
(S)-[4-(4-aminomethyl-phenoxy)-phenyl]-tert-butoxycarbonylamino-acetic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - -75 °C

1.2: -78 - 20 °C

2.1: pyridine; copper diacetate; triethylamine / dichloromethane / 4.5 h / 20 °C / Molecular sieve

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate

With pyridine; n-butyllithium; hydrogen; copper diacetate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate;

Reference yield:

: 914452-19-0
(S)-(4-benzyloxy-phenyl)-tert-butoxycarbonylamino-acetic acid benzyl ester

: 914452-63-4
(S)-[4-(4-aminomethyl-phenoxy)-phenyl]-tert-butoxycarbonylamino-acetic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide; water / 1,4-dioxane / 2 h / 20 °C

1.2: pH 3

2.1: pyridine; copper diacetate; triethylamine / dichloromethane / 4.5 h / 20 °C / Molecular sieve

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate

With pyridine; lithium hydroxide; water; hydrogen; copper diacetate; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; ethyl acetate;