{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-phenyl}-(S)-tert-butoxycarbonylamino-acetic acid cyclopentyl ester

Base Information

Chemical Name:{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-phenyl}-(S)-tert-butoxycarbonylamino-acetic acid cyclopentyl ester
CAS No.:914452-62-3
Molecular Formula:C₃₃H₃₈N₂O₇
Molecular Weight:574.674
Hs Code.:

Synonyms:{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-phenyl}-(S)-tert-butoxycarbonylamino-acetic acid cyclopentyl ester

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Chemical Property of {4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-phenyl}-(S)-tert-butoxycarbonylamino-acetic acid cyclopentyl ester

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Technology Process of {4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-phenyl}-(S)-tert-butoxycarbonylamino-acetic acid cyclopentyl ester

There total 5 articles about {4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-phenyl}-(S)-tert-butoxycarbonylamino-acetic acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 914452-61-2
α-benzyloxycarbonylamino-p-toluoylboronic acid

: 123593-66-8
L-N-(tert-butoxycarbonyl)-4-benzyloxyphenylglycine

: 914452-62-3
{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-phenyl}-(S)-tert-butoxycarbonylamino-acetic acid cyclopentyl ester

Guidance literature:: With pyridine; copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 4.5h; Molecular sieve;

Reference yield:

: 69651-48-5
N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine

: 914452-62-3
{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-phenyl}-(S)-tert-butoxycarbonylamino-acetic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 50 °C

2.1: lithium hydroxide; water / 1,4-dioxane / 2 h / 20 °C

2.2: pH 3

3.1: pyridine; copper diacetate; triethylamine / dichloromethane / 4.5 h / 20 °C / Molecular sieve

With pyridine; lithium hydroxide; water; copper diacetate; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 3959-07-7
4-Bromobenzylamine

: 914452-62-3
{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-phenyl}-(S)-tert-butoxycarbonylamino-acetic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 19 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - -75 °C

2.2: -78 - 20 °C

3.1: pyridine; copper diacetate; triethylamine / dichloromethane / 4.5 h / 20 °C / Molecular sieve

With pyridine; sodium hydroxide; n-butyllithium; copper diacetate; triethylamine; In tetrahydrofuran; hexane; dichloromethane; water;