2,4-Dichloro-benzoic acid (1R,4S)-4-acetoxy-cyclohex-2-enyl ester

Base Information

• Chemical Name: 2,4-Dichloro-benzoic acid (1R,4S)-4-acetoxy-cyclohex-2-enyl ester
• CAS No.: 189081-99-0
• Molecular Formula: C₁₅H₁₄Cl₂O₄
• Molecular Weight: 329.18
• Mol file: 189081-99-0.mol

Synonyms:2,4-Dichloro-benzoic acid (1R,4S)-4-acetoxy-cyclohex-2-enyl ester

Chemical Property of 2,4-Dichloro-benzoic acid (1R,4S)-4-acetoxy-cyclohex-2-enyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2,4-Dichloro-benzoic acid (1R,4S)-4-acetoxy-cyclohex-2-enyl ester

There total 1 articles about 2,4-Dichloro-benzoic acid (1R,4S)-4-acetoxy-cyclohex-2-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,4 dichlorobenzoic acid (50-84-0) + acetic acid (1S,4R)-(-)-4-hydroxycyclohex-2-enyl ester (132617-05-1) → 2,4-Dichloro-benzoic acid (1R,4S)-4-acetoxy-cyclohex-2-enyl ester (189081-99-0)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1039/a600779a

Reference yield: 73.0%

diethylamine (109-89-7) + 2,4-Dichloro-benzoic acid (1R,4S)-4-acetoxy-cyclohex-2-enyl ester (189081-99-0) → Acetic acid (1S,4R)-4-diethylamino-cyclohex-2-enyl ester (189081-89-8)

Guidance literature:

With triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; for 6h; Ambient temperature;

DOI:10.1039/a600779a

Reference yield: 72.0%

2-amino-1-benzylamine (4403-69-4) + 2,4-Dichloro-benzoic acid (1R,4S)-4-acetoxy-cyclohex-2-enyl ester (189081-99-0) → Acetic acid (1S,4R)-4-(2-amino-benzylamino)-cyclohex-2-enyl ester

Guidance literature:

With triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; for 18h; Ambient temperature;

DOI:10.1039/a702141k

upstream raw materials:

2,4 dichlorobenzoic acid

acetic acid (1S,4R)-(-)-4-hydroxycyclohex-2-enyl ester

Downstream raw materials:

Acetic acid (1S,4R)-4-diethylamino-cyclohex-2-enyl ester