3,5-dichloro-N-(4-((3,5-dichlorophenylsulfonamido)methyl)benzyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

Base Information

• Chemical Name: 3,5-dichloro-N-(4-((3,5-dichlorophenylsulfonamido)methyl)benzyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide
• CAS No.: 1201661-38-2
• Molecular Formula: C₂₇H₂₁Cl₄FN₂O₅S₂
• Molecular Weight: 678.417
• Mol file: 1201661-38-2.mol

Synonyms:3,5-dichloro-N-(4-((3,5-dichlorophenylsulfonamido)methyl)benzyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

Chemical Property of 3,5-dichloro-N-(4-((3,5-dichlorophenylsulfonamido)methyl)benzyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dichloro-N-(4-((3,5-dichlorophenylsulfonamido)methyl)benzyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

There total 4 articles about 3,5-dichloro-N-(4-((3,5-dichlorophenylsulfonamido)methyl)benzyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

3,5-dichlorobenzensulfonyl chloride (705-21-5) + N-(4-(aminomethyl)benzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide (1201663-67-3) → 3,5-dichloro-N-(4-((3,5-dichlorophenylsulfonamido)methyl)benzyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide (1201661-38-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

tert-butyl 4-((4-fluorobenzylamino)methyl)benzylcarbamate (1201663-65-1) → 3,5-dichloro-N-(4-((3,5-dichlorophenylsulfonamido)methyl)benzyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide (1201661-38-2)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

4-fluorobenzaldehyde (459-57-4) → 3,5-dichloro-N-(4-((3,5-dichlorophenylsulfonamido)methyl)benzyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide (1201661-38-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dichloromethane; isopropyl alcohol / 20 °C

1.2: 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; isopropyl alcohol;

upstream raw materials:

3,5-dichlorobenzensulfonyl chloride

N-(4-(aminomethyl)benzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

tert-butyl 4-((4-fluorobenzylamino)methyl)benzylcarbamate

4-fluorobenzaldehyde