C₁₆H₁₅Cl₂N₃O₅S₂

Base Information

Chemical Name:C₁₆H₁₅Cl₂N₃O₅S₂
CAS No.:1408186-80-0
Molecular Formula:C₁₆H₁₅Cl₂N₃O₅S₂
Molecular Weight:464.35
Hs Code.:

C<sub>16</sub>H<sub>15</sub>Cl<sub>2</sub>N<sub>3</sub>O<sub>5</sub>S<sub>2</sub>

Synonyms:C₁₆H₁₅Cl₂N₃O₅S₂

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Chemical Property of C₁₆H₁₅Cl₂N₃O₅S₂

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Technology Process of C₁₆H₁₅Cl₂N₃O₅S₂

There total 5 articles about C₁₆H₁₅Cl₂N₃O₅S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1408186-68-4
methyl (2R,4R)-1-(3,4-dichlorophenylsulfonyl)-4-(thiophene-2-carboxamido)pyrrolidine-2-carboxylate

: 1408186-80-0
C₁₆H₁₅Cl₂N₃O₅S₂

Guidance literature:: With hydroxylamine hydrochloride; potassium hydroxide; In methanol; at 20 ℃; for 72h;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 114676-47-0,775275-31-5,790644-51-8,754962-86-2
(2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester

: 1408186-80-0
C₁₆H₁₅Cl₂N₃O₅S₂

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

2: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 0.33 h / 0 - 90 °C / Microwave irradiation

3: sodium hydrogencarbonate / methanol / 0.25 h / 90 °C / Microwave irradiation

4: triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5: sodium azide / N,N-dimethyl-formamide / 90 °C

6: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

7: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

8: hydroxylamine hydrochloride; potassium hydroxide / methanol / 72 h / 20 °C

With dmap; sodium azide; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; methanesulfonyl chloride; triethylamine; triphenylphosphine; potassium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 1408186-45-7
methyl (2R,4R)-1-(3,4-dichlorophenylsulfonyl)-4-hydroxypyrrolidine-2-carboxylate

: 1408186-80-0
C₁₆H₁₅Cl₂N₃O₅S₂

Guidance literature:: Multi-step reaction with 7 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 0.33 h / 0 - 90 °C / Microwave irradiation

2: sodium hydrogencarbonate / methanol / 0.25 h / 90 °C / Microwave irradiation

3: triethylamine; methanesulfonyl chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4: sodium azide / N,N-dimethyl-formamide / 90 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

6: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

7: hydroxylamine hydrochloride; potassium hydroxide / methanol / 72 h / 20 °C

With sodium azide; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; methanesulfonyl chloride; triethylamine; triphenylphosphine; potassium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2012.08.028