N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

Base Information

Chemical Name:N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
CAS No.:1195778-87-0
Molecular Formula:C₃₀H₂₃F₂N₅O₄
Molecular Weight:555.541
Hs Code.:

N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

Synonyms:N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Property of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

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Technology Process of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

There total 10 articles about N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 888721-65-1
1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid

: 1195781-35-1
N-[6-(4-amino-3-fluorophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

: 1195778-87-0
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In ISOPROPYLAMIDE; at 20 ℃; for 20h;

Reference yield:

: 399-95-1
4-amino-3-fluorophenol

: 1195778-87-0
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

2.1: caesium carbonate / dimethyl sulfoxide / 6 h / 20 °C

3.1: water; iron; calcium chloride / ethanol / 8 h / Reflux

4.1: pyridine / 3 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

6.1: trifluoroacetic anhydride / tetrahydrofuran / 3 h / 20 °C

6.3: 4 h / 20 °C

7.1: ISOPROPYLAMIDE / 0 - 20 °C

8.1: water; barium(II) hydroxide / 1,2-dimethoxyethane / 16 h / 90 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / ISOPROPYLAMIDE / 20 h / 20 °C

With pyridine; water; iron; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic anhydride; calcium chloride; barium(II) hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; ISOPROPYLAMIDE; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1175127-62-4
1-(4-fluorophenyl)-6-methyl-3-cyano-2-oxo-1,2-dihydropyridine

: 1195778-87-0
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid; water / 20 h / 120 °C

2: N-ethyl-N,N-diisopropylamine; HATU / ISOPROPYLAMIDE / 20 h / 20 °C

With sulfuric acid; water; N-ethyl-N,N-diisopropylamine; HATU; In ISOPROPYLAMIDE;