N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide p-toluenesulfonate

Base Information

Chemical Name:N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide p-toluenesulfonate
CAS No.:1195780-84-7
Molecular Formula:C₇H₈O₃S*C₃₀H₂₃F₂N₅O₄
Molecular Weight:727.745
Hs Code.:

N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide p-toluenesulfonate

Synonyms:N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide p-toluenesulfonate

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Chemical Property of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide p-toluenesulfonate

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Technology Process of N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide p-toluenesulfonate

There total 11 articles about N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1195778-87-0
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide

: 104-15-4
toluene-4-sulfonic acid

: 1195780-84-7
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide p-toluenesulfonate

Guidance literature:: In tetrahydrofuran; at 40 - 60 ℃;

Reference yield:

: 399-95-1
4-amino-3-fluorophenol

: 1195780-84-7
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide p-toluenesulfonate

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C

2.1: caesium carbonate / dimethyl sulfoxide / 6 h / 20 °C

3.1: water; iron; calcium chloride / ethanol / 8 h / Reflux

4.1: pyridine / 3 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

6.1: trifluoroacetic anhydride / tetrahydrofuran / 3 h / 20 °C

6.3: 4 h / 20 °C

7.1: ISOPROPYLAMIDE / 0 - 20 °C

8.1: water; barium(II) hydroxide / 1,2-dimethoxyethane / 16 h / 90 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / ISOPROPYLAMIDE / 20 h / 20 °C

10.1: tetrahydrofuran / 40 - 60 °C

With pyridine; water; iron; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic anhydride; calcium chloride; barium(II) hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; ISOPROPYLAMIDE; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1175127-62-4
1-(4-fluorophenyl)-6-methyl-3-cyano-2-oxo-1,2-dihydropyridine

: 1195780-84-7
N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-2-fluorophenyl]-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide p-toluenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; water / 20 h / 120 °C

2: N-ethyl-N,N-diisopropylamine; HATU / ISOPROPYLAMIDE / 20 h / 20 °C

3: tetrahydrofuran / 40 - 60 °C

With sulfuric acid; water; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; ISOPROPYLAMIDE;