1-(p-toluenesulfonyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one

Base Information

• Chemical Name: 1-(p-toluenesulfonyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one
• CAS No.: 852615-13-5
• Molecular Formula: C₁₂H₁₂N₂O₅S
• Molecular Weight: 296.304

Synonyms:1-(p-toluenesulfonyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one

Chemical Property of 1-(p-toluenesulfonyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one

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Technology Process of 1-(p-toluenesulfonyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one

There total 1 articles about 1-(p-toluenesulfonyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

p-toluenesulfonyl chloride (98-59-9) + methyl 2-oxo-2,3-dihydro-1H-imidazole-4-carboxylate (20901-53-5) → 1-(p-toluenesulfonyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one (852615-13-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 65 ℃; for 19h;

DOI:10.1021/ol0473602

Reference yield: 95.0%

1-(p-toluenesulfonyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one (852615-13-5) + 4-chloromethyl-1,2-dimethoxy-benzene (7306-46-9) → 1-(p-toluenesulfonyl)-3-(3,4-dimethoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one (852615-14-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 20h;

DOI:10.1021/ol0473602

Reference yield: 83.0%

1-(p-toluenesulfonyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one (852615-13-5) + p-Methoxybenzyl bromide (2746-25-0) → 1-(p-toluenesulfonyl)-3-(4-methoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one (896141-29-0)

Guidance literature:

With potassium carbonate; In acetonitrile; at 70 ℃;

DOI:10.1016/j.tet.2005.12.068

upstream raw materials:

p-toluenesulfonyl chloride

methyl 2-oxo-2,3-dihydro-1H-imidazole-4-carboxylate

Downstream raw materials:

1-(p-toluenesulfonyl)-3-(3,4-dimethoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one

1-(p-toluenesulfonyl)-3-(4-methoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one

3-(3,4-dimethoxybenzyl)-1-(toluene-4-sulfonyl)-4-formyl-2,3-dihydro-1H-imidazol-2-one

3-(3,4-dimethoxybenzyl)-1-(toluene-4-sulfonyl)-4-(hydroxymethyl)-1,3-dihydro-imidazol-2-one

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