20901-53-5

Usage

Uses

Used in Pharmaceutical Research:
Methyl 2,3-dihydro-2-oxo-1H-imidazole-4-carboxylate is utilized as a precursor in the synthesis of bioactive compounds for potential drug development. Its role is pivotal in creating new therapeutic agents due to its unique structural properties and reactivity.
Used in Antifungal and Antibacterial Applications:
In the field of antimicrobial research, methyl 2,3-dihydro-2-oxo-1H-imidazole-4-carboxylate is employed as an active ingredient for its potential antifungal and antibacterial properties. It contributes to the development of treatments targeting a range of microbial infections.
Used in Enzyme and Receptor Inhibition:
Methyl 2,3-dihydro-2-oxo-1H-imidazole-4-carboxylate is also used as an inhibitor of certain enzymes and receptors in the human body. Its application in this area is crucial for the modulation of biological processes and the treatment of related disorders.
Used in Organic Synthesis:
In the realm of organic chemistry, methyl 2,3-dihydro-2-oxo-1H-imidazole-4-carboxylate serves as a key intermediate in various synthetic pathways, facilitating the creation of complex organic molecules for a multitude of applications.
Used in Medicinal Chemistry:
Methyl 2,3-dihydro-2-oxo-1H-imidazole-4-carboxylate is applied in medicinal chemistry for the design of pharmaceuticals, leveraging its structural attributes to enhance drug efficacy and selectivity.

InChI:InChI=1/C5H6N2O3/c1-10-4(8)3-2-6-5(9)7-3/h2H,1H3,(H2,6,7,9)

Upstream product

• 67-56-1 methanol 
• 39828-47-2 2-oxo-4-imidazoline-4-carboxylic acid 
• 157001-86-0 methyl (4S)-2-oxoimidazolidine-4-carboxylate 

Downstream Products

• 852615-13-5 1-(p-toluenesulfonyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one 
• 852615-14-6 1-(p-toluenesulfonyl)-3-(3,4-dimethoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one 
• 852615-23-7 3-(3,4-dimethoxybenzyl)-2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carboxylic acid methyl ester 
• 896141-27-8 1-tert-butoxycarbonyl-3-(4-methoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one 
• 896141-29-0 1-(p-toluenesulfonyl)-3-(4-methoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one 
• 852615-22-6 2-oxo-1-[2-(toluene-4-sulfonyl)-ethyl]-2,3-dihydro-1H-imidazole-4-carboxylic acid methyl ester 
• 896141-17-6 1,3-bis(benzyloxymethyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one 
• 852615-18-0 2-oxo-1-[2-(toluene-4-sulfonyl)-vinyl]-2,3-dihydro-1H-imidazole-4-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Diastereoselective Cycloaddition of Allyltrialkylsilanes to Intermediate N-Acyliminoesters Obtained from Methyl 4-Methoxy-2-Imidazolidinone- and 2-Oxazolidinone-4-carboxylates

The amidoalkylation reaction of methyl 4-methoxy-2-imidazolidinone-4-carboxylates or methyl 4-methoxy-2-oxazolidinone-4-carboxylates using allylsilanes as nucleophiles in the presence of TiCl4 affords three carbon ring annulation products 5 and 9 via a cycloaddition.Besides that, the simple methoxy group substitution product is formed.The ring annulation occurs with practically total diastereoselectivity so that all substituents are located on the β-side of the bicyclic product.

A unified synthetic strategy toward oroidin-derived alkaloids premised on a biosynthetic proposal

Details of the evolution of a synthetic strategy toward the spirocyclic chlorocyclopentane core of oroidin-derived alkaloids, including the axinellamines and potentially adaptable to palau'amine, are described. A proposed refinement of the Kinnel-Scheuer biosynthetic proposal for palau'amine is posited. Studies undertaken to improve the regioselectivity and efficiency of a key Diels-Alder reaction utilizing a novel protecting group strategy, microwave chemistry, and other strategies are described. Further insights regarding the suitability of different protecting groups during the epoxidation/chlorination/ring contraction sequence are disclosed. Several interesting by-products from this reaction sequence are reported. These studies have led to a unified synthetic strategy to the axinellamines and palau'amine.