1-(p-toluenesulfonyl)-3-(4-methoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one

Base Information

• Chemical Name: 1-(p-toluenesulfonyl)-3-(4-methoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one
• CAS No.: 896141-29-0
• Molecular Formula: C₂₀H₂₀N₂O₆S
• Molecular Weight: 416.455

Synonyms:1-(p-toluenesulfonyl)-3-(4-methoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one

Chemical Property of 1-(p-toluenesulfonyl)-3-(4-methoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1-(p-toluenesulfonyl)-3-(4-methoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one

There total 3 articles about 1-(p-toluenesulfonyl)-3-(4-methoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-(p-toluenesulfonyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one (852615-13-5) + p-Methoxybenzyl bromide (2746-25-0) → 1-(p-toluenesulfonyl)-3-(4-methoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one (896141-29-0)

Guidance literature:

With potassium carbonate; In acetonitrile; at 70 ℃;

DOI:10.1016/j.tet.2005.12.068

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 1-(p-toluenesulfonyl)-3-(4-methoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one (896141-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / NaH / dimethylformamide / 19 h / 0 - 65 °C

2: 83 percent / K₂CO₃ / acetonitrile / 70 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tet.2005.12.068

Reference yield:

methyl 2-oxo-2,3-dihydro-1H-imidazole-4-carboxylate (20901-53-5) → 1-(p-toluenesulfonyl)-3-(4-methoxybenzyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one (896141-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / NaH / dimethylformamide / 19 h / 0 - 65 °C

2: 83 percent / K₂CO₃ / acetonitrile / 70 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tet.2005.12.068

upstream raw materials:

1-(p-toluenesulfonyl)-4-(methoxycarbonyl)-2,3-dihydro-1H-imidazol-2-one

p-Methoxybenzyl bromide

p-toluenesulfonyl chloride

methyl 2-oxo-2,3-dihydro-1H-imidazole-4-carboxylate

Downstream raw materials:

3-(4-methoxybenzyl)-1-(toluene-4-sulfonyl)-4-(hydroxymethyl)-1,3-dihydro-imidazol-2-one

(5R,5aS,8S,8aS)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(4-methoxy-benzyl)-1,7-bis-(toluene-4-sulfonyl)-8-triisopropylsilanyloxymethyl-1,3,4,5,5a,7,8,8a-octahydro-imidazo[4,5-e]isoindole-2,6-dione

(5R,5aS,8S,8aS)-5-Hydroxymethyl-3-(4-methoxy-benzyl)-1,7-bis-(toluene-4-sulfonyl)-8-triisopropylsilanyloxymethyl-1,3,4,5,5a,7,8,8a-octahydro-imidazo[4,5-e]isoindole-2,6-dione

(5R,5aS,8S,8aS)-5-Hydroxymethyl-3-(4-methoxy-benzyl)-8-triisopropylsilanyloxymethyl-1,3,4,5,5a,7,8,8a-octahydro-imidazo[4,5-e]isoindole-2,6-dione

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