(3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanoic acid

Base Information

Chemical Name:(3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanoic acid
CAS No.:479480-63-2
Molecular Formula:C₁₃H₂₃F₂NO₃S
Molecular Weight:311.393
Hs Code.:

Synonyms:(3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanoic acid

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Chemical Property of (3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanoic acid

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Technology Process of (3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanoic acid

There total 3 articles about (3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 479480-54-1
ethyl (3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanoate

: 479480-63-2
(3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanoic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 60 ℃; for 18h;
DOI:10.1021/jo0259313

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 479480-63-2
(3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: CuSO₄; molecular sieves / CH₂Cl₂

2.1: Zn / tetrahydrofuran

2.2: tetrahydrofuran / 18 h / 20 °C

3.1: 48 percent / NaOH / ethanol / 18 h / 60 °C

With sodium hydroxide; molecular sieve; copper(II) sulfate; zinc; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo0259313

Reference yield:

: 336105-28-3
(R_S,E)-N-(cyclohexylmethylene)-2-methylpropane-2-sulfinamide

: 479480-63-2
(3R)-3-[(tert-butylsulfinyl)amino]-3-cyclohexyl-2,2-difluoropropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: Zn / tetrahydrofuran

1.2: tetrahydrofuran / 18 h / 20 °C

2.1: 48 percent / NaOH / ethanol / 18 h / 60 °C

With sodium hydroxide; zinc; In tetrahydrofuran; ethanol;
DOI:10.1021/jo0259313