4-[2-(1,3-dihydroisoindol-2-yl)-1-hydroxyethyl]-1-dimethylaminocyclohexanecarbonitrile

Base Information

Chemical Name:4-[2-(1,3-dihydroisoindol-2-yl)-1-hydroxyethyl]-1-dimethylaminocyclohexanecarbonitrile
CAS No.:1189555-59-6
Molecular Formula:C₁₉H₂₇N₃O
Molecular Weight:313.443
Hs Code.:

Synonyms:4-[2-(1,3-dihydroisoindol-2-yl)-1-hydroxyethyl]-1-dimethylaminocyclohexanecarbonitrile

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Chemical Property of 4-[2-(1,3-dihydroisoindol-2-yl)-1-hydroxyethyl]-1-dimethylaminocyclohexanecarbonitrile

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Technology Process of 4-[2-(1,3-dihydroisoindol-2-yl)-1-hydroxyethyl]-1-dimethylaminocyclohexanecarbonitrile

There total 5 articles about 4-[2-(1,3-dihydroisoindol-2-yl)-1-hydroxyethyl]-1-dimethylaminocyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: potassium cyanide

: 1189555-58-5
4-[2-(1,3-dihydroisoindol-2-yl)-1-hydroxyethyl]cyclohexanone

: 124-40-3
dimethyl amine

: 1189555-59-6
4-[2-(1,3-dihydroisoindol-2-yl)-1-hydroxyethyl]-1-dimethylaminocyclohexanecarbonitrile

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃;

Reference yield:

: 496-12-8
isoindoline

: 1189555-59-6
4-[2-(1,3-dihydroisoindol-2-yl)-1-hydroxyethyl]-1-dimethylaminocyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: calcium(II) trifluoromethanesulfonate / acetonitrile / 20 °C

2: hydrogenchloride; water / acetone / 20 °C

3: hydrogenchloride / water; tetrahydrofuran; methanol / 20 °C

With hydrogenchloride; water; calcium(II) trifluoromethanesulfonate; In tetrahydrofuran; methanol; water; acetone; acetonitrile;

Reference yield:

: 93245-98-8
1,4-dioxaspiro[4.5]decane-8-carbaldehyde

: 1189555-59-6
4-[2-(1,3-dihydroisoindol-2-yl)-1-hydroxyethyl]-1-dimethylaminocyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.75 h / 20 °C

1.2: 18 h / 60 °C

2.1: calcium(II) trifluoromethanesulfonate / acetonitrile / 20 °C

3.1: hydrogenchloride; water / acetone / 20 °C

4.1: hydrogenchloride / water; tetrahydrofuran; methanol / 20 °C

With hydrogenchloride; water; sodium hydride; calcium(II) trifluoromethanesulfonate; In tetrahydrofuran; methanol; water; dimethyl sulfoxide; acetone; acetonitrile; mineral oil;