N₃-(4-methoxyphenyl)-N₅-(2-(trifluoromethyl)phenyl)-1H-pyrazole-3,5-diamine

Base Information

Chemical Name:N₃-(4-methoxyphenyl)-N₅-(2-(trifluoromethyl)phenyl)-1H-pyrazole-3,5-diamine
CAS No.:1351624-72-0
Molecular Formula:C₁₇H₁₅F₃N₄O
Molecular Weight:348.328
Hs Code.:

N<sub>3</sub>-(4-methoxyphenyl)-N<sub>5</sub>-(2-(trifluoromethyl)phenyl)-1H-pyrazole-3,5-diamine

Synonyms:N₃-(4-methoxyphenyl)-N₅-(2-(trifluoromethyl)phenyl)-1H-pyrazole-3,5-diamine

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Chemical Property of N₃-(4-methoxyphenyl)-N₅-(2-(trifluoromethyl)phenyl)-1H-pyrazole-3,5-diamine

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Technology Process of N₃-(4-methoxyphenyl)-N₅-(2-(trifluoromethyl)phenyl)-1H-pyrazole-3,5-diamine

There total 3 articles about N₃-(4-methoxyphenyl)-N₅-(2-(trifluoromethyl)phenyl)-1H-pyrazole-3,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 1743-86-8
2-(trifluoromethyl)phenyl isothiocyanate

: 1118-67-8
sodium (Z)-4-oxopent-2-en-2-olate

: 2284-20-0
4-Methoxyphenyl isothiocyanate

: 1351624-72-0
N₃-(4-methoxyphenyl)-N₅-(2-(trifluoromethyl)phenyl)-1H-pyrazole-3,5-diamine

: 1351624-83-3
N₃,N₅-bis(2-(trifluoromethyl)phenyl)-1H-pyrazole-3,5-diamine

: 62802-24-8
N₃,N₅-bis(4-methoxyphenyl)-1H-pyrazole-3,5-diamine

Guidance literature:: 2-(trifluoromethyl)phenyl isothiocyanate; sodium (Z)-4-oxopent-2-en-2-olate; 4-Methoxyphenyl isothiocyanate; In ethyl methyl ether; at 20 ℃; for 48h; Inert atmosphere; Combinatorial reaction / High throughput screening (HTS);

With hydrazine hydrate; In ethyl methyl ether; at 85 ℃; for 2h; Combinatorial reaction / High throughput screening (HTS); Inert atmosphere;
DOI:10.1016/j.tetlet.2011.09.150

Reference yield:

: 88-17-5
2-(trifluoromethyl)benzenamine

: 1351624-72-0
N₃-(4-methoxyphenyl)-N₅-(2-(trifluoromethyl)phenyl)-1H-pyrazole-3,5-diamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

2.1: ethyl methyl ether / 48 h / 20 °C / Inert atmosphere; Combinatorial reaction / High throughput screening (HTS)

2.2: 2 h / 85 °C / Combinatorial reaction / High throughput screening (HTS); Inert atmosphere

With triethylamine; In tetrahydrofuran; ethyl methyl ether;
DOI:10.1016/j.tetlet.2011.09.150

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1351624-72-0
N₃-(4-methoxyphenyl)-N₅-(2-(trifluoromethyl)phenyl)-1H-pyrazole-3,5-diamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

2.1: ethyl methyl ether / 48 h / 20 °C / Inert atmosphere; Combinatorial reaction / High throughput screening (HTS)

2.2: 2 h / 85 °C / Combinatorial reaction / High throughput screening (HTS); Inert atmosphere

With triethylamine; In tetrahydrofuran; ethyl methyl ether;
DOI:10.1016/j.tetlet.2011.09.150